Is the serum level of salusin-ß associated with hypertension and atherosclerosis in the pediatric population?
Pediatr Nephrol
; 30(3): 523-31, 2015 Mar.
Article
en En
| MEDLINE
| ID: mdl-25245503
ABSTRACT
BACKGROUND:
Salusins are recently identified endogenous bioactive peptides that have hypotensive and bradycardiac effects. Salusin-ß is involved in the pathogenesis of human atherosclerosis.METHODS:
This was a prospective cohort study of a young patient population with hypertension (HTN). Based on ambulatory blood pressure monitoring (ABPM), the adolescents were categorized into two groups, namely, a hypertensive group consisting of patients with essential (primary) HTN (HTN group) and a group consisting of patients with white-coat HTN [reference (R) group]. Correlations between serum salusin-ß level and clinical, laboratory and ambulatory blood pressure (BP) variables were assessed.RESULTS:
The median salusin-ß concentration was significantly higher in patients with essential HTN than in those with white-coat HTN (R group). Salusin-ß was positively correlated with the body mass index Z-score, systolic and diastolic blood pressure (BP) from three independent measurements, mean systolic BP during the daytime, triglyceride (TG) level, and atherogenic index (TG/high-density lipoprotein-cholesterol ratio).CONCLUSIONS:
The results of this preliminary study suggest that salusin-ß may play an important role in the pathogenesis of HTN in a young population. Further research should focus on the role of salusin-ß in the mechanism of essential HTN and the assessment of possible correlations between salusin-ß and other well-known markers of atherosclerosis in both teenagers and adults. This research should serve as a base for future studies in this field.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Péptidos y Proteínas de Señalización Intercelular
/
Aterosclerosis
/
Hipertensión
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Child
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Female
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Humans
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Male
Idioma:
En
Año:
2015
Tipo del documento:
Article