Biodegradable composite scaffolds of bioactive glass/chitosan/carboxymethyl cellulose for hemostatic and bone regeneration.
Biotechnol Lett
; 37(2): 457-65, 2015 Feb.
Article
en En
| MEDLINE
| ID: mdl-25326173
ABSTRACT
Hemostasis in orthopedic osteotomy or bone cutting requires different methods and materials. The bleeding of bone marrow can be mostly stopped by bone wax. However, the wax cannot be absorbed, which leads to artificial prosthesis loosening, foreign matter reaction, and infection. Here, a bioactive glass/chitosan/carboxymethyl cellulose (BG/CS/CMC) composite scaffold was designed to replace traditional wax. WST-1 assay indicated the BG/CS/CMC composite resulted in excellent biocompatibility with no cytotoxicity. In vivo osteogenesis assessment revealed that the BG/CS/CMC composite played a dominant role in bone regeneration and hemostasis. The BG/CS/CMC composite had the same hemostasis effect as bone wax; in addition its biodegradation also led to the functional reconstruction of bone defects. Thus, BG/CS/CMC scaffolds can serve as a potential material for bone repair and hemostasis in critical-sized bone defects.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Carboximetilcelulosa de Sodio
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Hemostáticos
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Sustitutos de Huesos
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Quitosano
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Andamios del Tejido
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Vidrio
Límite:
Animals
Idioma:
En
Año:
2015
Tipo del documento:
Article