E2F transcription factor 1 regulates cellular and organismal senescence by inhibiting Forkhead box O transcription factors.

Xie, Qi; Peng, Shengyi; Tao, Li; Ruan, Haihe; Yang, Yanglu; Li, Tie-Mei; Adams, Ursula; Meng, Songshu; Bi, Xiaolin; Dong, Meng-Qiu; Yuan, Zengqiang

Xie, Qi; Peng, Shengyi; Tao, Li; Ruan, Haihe; Yang, Yanglu; Li, Tie-Mei; Adams, Ursula; Meng, Songshu; Bi, Xiaolin; Dong, Meng-Qiu; Yuan, Zengqiang.

Xie Q; From the State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Peng S; From the State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China, College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049.
Tao L; National Institute of Biological Sciences, Beijing 102206, China.
Ruan H; From the State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Yang Y; From the State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China, College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049.
Li TM; National Institute of Biological Sciences, Beijing 102206, China.
Adams U; Biological Sciences, The University of Chicago, Chicago, Illinois 60637, and.
Meng S; Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Dalian 116044, China.
Bi X; Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Dalian 116044, China.
Dong MQ; National Institute of Biological Sciences, Beijing 102206, China.
Yuan Z; From the State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China, zqyuan@sun5.ibp.ac.cn.

J Biol Chem ; 289(49): 34205-13, 2014 Dec 05.

Article en En | MEDLINE | ID: mdl-25344604

Asunto(s)

Envejecimiento/genética; Caenorhabditis elegans/genética; Senescencia Celular/genética; Factor de Transcripción E2F1/genética; Fibroblastos/metabolismo; Factores de Transcripción Forkhead/genética; Envejecimiento/metabolismo; Animales; Sitios de Unión; Caenorhabditis elegans/metabolismo; Proteínas de Caenorhabditis elegans/genética; Proteínas de Caenorhabditis elegans/metabolismo; Catalasa/genética; Catalasa/metabolismo; Línea Celular; Factores de Transcripción E2F/genética; Factores de Transcripción E2F/metabolismo; Factor de Transcripción E2F1/antagonistas & inhibidores; Factor de Transcripción E2F1/metabolismo; Embrión de Mamíferos; Fibroblastos/citología; Proteína Forkhead Box O3; Factores de Transcripción Forkhead/metabolismo; Regulación del Desarrollo de la Expresión Génica; Células HEK293; Humanos; Longevidad/genética; Ratones; Unión Proteica; Dominios y Motivos de Interacción de Proteínas; ARN Interferente Pequeño/genética; ARN Interferente Pequeño/metabolismo; Transducción de Señal; Superóxido Dismutasa/genética; Superóxido Dismutasa/metabolismo; Factores de Transcripción/genética; Factores de Transcripción/metabolismo

Palabras clave

E2F Transcription Factor; FOXO; Oxidative Stress; Senescence; Transcription Regulation

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Envejecimiento / Senescencia Celular / Caenorhabditis elegans / Factores de Transcripción Forkhead / Factor de Transcripción E2F1 / Fibroblastos Idioma: En Año: 2014 Tipo del documento: Article

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