p100/I&#954;BÎ´ sequesters and inhibits NF-&#954;B through kappaBsome formation.

Tao, Zhihua; Fusco, Amanda; Huang, De-Bin; Gupta, Kushol; Young Kim, Daniel; Ware, Carl F; Van Duyne, Gregory D; Ghosh, Gourisankar

p100/IκBÎ´ sequesters and inhibits NF-κB through kappaBsome formation.

Tao, Zhihua; Fusco, Amanda; Huang, De-Bin; Gupta, Kushol; Young Kim, Daniel; Ware, Carl F; Van Duyne, Gregory D; Ghosh, Gourisankar.

Tao Z; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093;
Fusco A; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093;
Huang DB; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093;
Gupta K; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104; and.
Young Kim D; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093;
Ware CF; Infectious and Inflammatory Diseases Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037.
Van Duyne GD; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104; and.
Ghosh G; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093; gghosh@ucsd.edu.

Proc Natl Acad Sci U S A ; 111(45): 15946-51, 2014 Nov 11.

Article en En | MEDLINE | ID: mdl-25349408

Asunto(s)

Proteínas I-kappa B; Complejos Multiproteicos; Subunidad p52 de NF-kappa B; Proteínas; Proteolisis; Células 3T3; Animales; Cristalografía por Rayos X; Humanos; Proteínas I-kappa B/química; Proteínas I-kappa B/genética; Proteínas I-kappa B/metabolismo; Péptidos y Proteínas de Señalización Intracelular; Ratones; Ratones Noqueados; Complejos Multiproteicos/química; Complejos Multiproteicos/genética; Complejos Multiproteicos/metabolismo; Subunidad p52 de NF-kappa B/química; Subunidad p52 de NF-kappa B/genética; Subunidad p52 de NF-kappa B/metabolismo; Fragmentos de Péptidos/genética; Fragmentos de Péptidos/metabolismo; Estructura Cuaternaria de Proteína; Estructura Terciaria de Proteína; Proteínas/química; Proteínas/genética; Proteínas/metabolismo; Factores de Transcripción/genética; Factores de Transcripción/metabolismo

Palabras clave

IκB; NF-κB; kappaBsome; structure; transcription

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas / Proteínas I-kappa B / Complejos Multiproteicos / Subunidad p52 de NF-kappa B / Proteolisis Límite: Animals / Humans Idioma: En Año: 2014 Tipo del documento: Article

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