The E3 ubiquitin ligase thyroid hormone receptor-interacting protein 12 targets pancreas transcription factor 1a for proteasomal degradation.

Hanoun, Naïma; Fritsch, Samuel; Gayet, Odile; Gigoux, Véronique; Cordelier, Pierre; Dusetti, Nelson; Torrisani, Jérôme; Dufresne, Marlène

Hanoun, Naïma; Fritsch, Samuel; Gayet, Odile; Gigoux, Véronique; Cordelier, Pierre; Dusetti, Nelson; Torrisani, Jérôme; Dufresne, Marlène.

Hanoun N; From the INSERM UMR1037, Cancer Research Center of Toulouse (CRCT), University of Toulouse III Paul Sabatier, 31037 Toulouse, France.
Fritsch S; From the INSERM UMR1037, Cancer Research Center of Toulouse (CRCT), University of Toulouse III Paul Sabatier, 31037 Toulouse, France.
Gayet O; the Cancer Research Center of Marseille, INSERM UMR1068, Paoli-Calmettes Institute, University of Aix-Marseille, CNRS UMR7258, 13273 Marseille, France.
Gigoux V; EA 4552, University of Toulouse III Paul Sabatier, 31432 Toulouse, France, and.
Cordelier P; From the INSERM UMR1037, Cancer Research Center of Toulouse (CRCT), University of Toulouse III Paul Sabatier, 31037 Toulouse, France.
Dusetti N; the Cancer Research Center of Marseille, INSERM UMR1068, Paoli-Calmettes Institute, University of Aix-Marseille, CNRS UMR7258, 13273 Marseille, France.
Torrisani J; From the INSERM UMR1037, Cancer Research Center of Toulouse (CRCT), University of Toulouse III Paul Sabatier, 31037 Toulouse, France.
Dufresne M; From the INSERM UMR1037, Cancer Research Center of Toulouse (CRCT), University of Toulouse III Paul Sabatier, 31037 Toulouse, France, marlene.dufresne@inserm.fr.

J Biol Chem ; 289(51): 35593-604, 2014 Dec 19.

Article en En | MEDLINE | ID: mdl-25355311

Asunto(s)

Proteínas Portadoras/metabolismo; Complejo de la Endopetidasa Proteasomal/metabolismo; Factores de Transcripción/metabolismo; Ubiquitina-Proteína Ligasas/metabolismo; Células Acinares/metabolismo; Células Acinares/patología; Animales; Western Blotting; Proteínas Portadoras/genética; Línea Celular Tumoral; Proliferación Celular; Citoplasma/metabolismo; Células HEK293; Humanos; Mutación Missense; Neoplasias Pancreáticas/patología; Unión Proteica; Estabilidad Proteica; Proteolisis; Reacción en Cadena de la Polimerasa de Transcriptasa Inversa; Factores de Transcripción/genética; Técnicas del Sistema de Dos Híbridos; Ubiquitina-Proteína Ligasas/genética; Ubiquitinación

Palabras clave

Basic Helix-Loop-Helix Transcription Factor (bHLH); E3 Ubiquitin Ligase; Pancreas; Pancreatic Cancer; Proteasome; Protein Degradation; Protein-Protein Interaction; Transcription Factor; Ubiquitylation (Ubiquitination); Yeast Two-Hybrid

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Factores de Transcripción / Proteínas Portadoras / Ubiquitina-Proteína Ligasas / Complejo de la Endopetidasa Proteasomal Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2014 Tipo del documento: Article

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