Cord blood and consecutive chitotriosidase activity: Relationship to prematurity and early prognosis.
Pediatr Int
; 57(3): 414-21, 2015 Jun.
Article
en En
| MEDLINE
| ID: mdl-25367205
ABSTRACT
BACKGROUND:
The aim of this study was to investigate the relationship between plasma chitotriosidase activity, an inflammatory protein secreted mainly from macrophages, and neonatal morbidity and mortality in premature infants.METHODS:
Cord blood chitotriosidase activity was studied in healthy control infants (53 term, group 1; 26 late preterm [33-37 gestational weeks], group 2) and 35 preterm infants (≤ 32 weeks; group 3). In group 3, consecutive samples at 3 h, 24 h, 72 h, 7 days, 14 days, and 36 weeks after conception were also analyzed. Group 3 was also evaluated for mortality, respiratory treatment and bronchopulmonary dysplasia (BPD), patent ductus arteriosus (PDA), intraventricular hemorrhage (IVH) and retinopathy of prematurity (ROP) and necrotizing enterocolitis (NEC).RESULTS:
Cord blood chitotriosidase activity was positively correlated with gestational age and birthweight. SNAPPE-II score was correlated with chitotriosidase activity at 24 h. Consecutive chitotriosidase activity for group 3 was non-significantly higher in infants who died in the early neonatal period. Higher chitotriosidase activity was observed in mechanically ventilated infants than infants treated with non-invasive assisted ventilation. BPD, PDA, IVH and ROP, but not NEC, were related to higher chitotriosidase activity, being significant at some of the time points.CONCLUSION:
Neonatal stress such as invasive ventilation may create a risk for the development of BPD, PDA, IVH, and ROP by increasing macrophage activation in preterm infants as reflected in the higher chitotriosidase activity. High chitotriosidase activity may also be associated with disease severity and mortality.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Recien Nacido Prematuro
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Sangre Fetal
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Hexosaminidasas
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Enfermedades del Prematuro
Tipo de estudio:
Prognostic_studies
Límite:
Female
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Humans
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Male
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Newborn
País como asunto:
Asia
Idioma:
En
Año:
2015
Tipo del documento:
Article