Sc(OTf)3-mediated 1,3-dipolar cycloaddition-ring cleavage-rearrangement: a highly stereoselective access to Z-ß-enaminonitriles.
Org Biomol Chem
; 13(2): 513-9, 2015 Jan 14.
Article
en En
| MEDLINE
| ID: mdl-25375635
ABSTRACT
A novel and highly stereoselective synthesis of Z-ß-enaminonitriles from azides and α,ß-unsaturated nitriles is reported. The reaction proceeds via a 1,3-dipolar cycloaddition-ring cleavage-rearrangement cascade mediated by a catalytic amount of Sc(OTf)3. A plausible reaction mechanism for this process is depicted.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Reacción de Cicloadición
/
Nitrilos
Idioma:
En
Año:
2015
Tipo del documento:
Article