Optimized on-line enantioselective capillary electrophoretic method for kinetic and inhibition studies of drug metabolism mediated by cytochrome P450 enzymes.

Remínek, Roman; Glatz, Zdenek; Thormann, Wolfgang

Remínek, Roman; Glatz, Zdenek; Thormann, Wolfgang.

Remínek R; Department of Biochemistry, Faculty of Science and CEITEC-Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Glatz Z; Clinical Pharmacology Laboratory, Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
Thormann W; Department of Biochemistry, Faculty of Science and CEITEC-Central European Institute of Technology, Masaryk University, Brno, Czech Republic.

Electrophoresis ; 36(11-12): 1349-57, 2015 Jun.

Article en En | MEDLINE | ID: mdl-25382218

Asunto(s)

Inhibidores Enzimáticos del Citocromo P-450/farmacología; Sistema Enzimático del Citocromo P-450/metabolismo; Electroforesis Capilar/métodos; Dexmedetomidina/metabolismo; Dexmedetomidina/farmacocinética; Ketamina/metabolismo; Ketamina/farmacocinética; Cetoconazol/metabolismo; Cetoconazol/farmacocinética; Estereoisomerismo; gamma-Ciclodextrinas/metabolismo; gamma-Ciclodextrinas/farmacocinética

Palabras clave

Capillary electrophoresis; Cytochrome P450 3A4; Dexmedetomidine; Enantioselective drug metabolism; Ketamine; Ketoconazole

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Electroforesis Capilar / Sistema Enzimático del Citocromo P-450 / Inhibidores Enzimáticos del Citocromo P-450 Idioma: En Año: 2015 Tipo del documento: Article

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