Synthesis, molecular modeling, and biological evaluation of novel chiral thiosemicarbazone derivatives as potent anticancer agents.
Chirality
; 27(2): 177-88, 2015 Feb.
Article
en En
| MEDLINE
| ID: mdl-25399965
ABSTRACT
A series of new chiral thiosemicarbazones derived from homochiral amines in both enantiomeric forms were synthesized and evaluated for their in vitro antiproliferative activity against A549 (human alveolar adenocarcinoma), MCF-7 (human breast adenocarcinoma), HeLa (human cervical adenocarcinoma), and HGC-27 (human stomach carcinoma) cell lines. Some of compounds showed inhibitory activities on the growth of cancer cell lines. Especially, compound exhibited the most potent activity (IC50 4.6 µM) against HGC-27 as compared with the reference compound, sindaxel (IC50 10.3 µM), and could be used as a lead compound to search new chiral thiosemicarbazone derivatives as antiproliferative agents.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tiosemicarbazonas
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Año:
2015
Tipo del documento:
Article