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TUBB3/ßIII-tubulin acts through the PTEN/AKT signaling axis to promote tumorigenesis and anoikis resistance in non-small cell lung cancer.
McCarroll, Joshua A; Gan, Pei Pei; Erlich, Rafael B; Liu, Marjorie; Dwarte, Tanya; Sagnella, Sharon S; Akerfeldt, Mia C; Yang, Lu; Parker, Amelia L; Chang, Melissa H; Shum, Michael S; Byrne, Frances L; Kavallaris, Maria.
  • McCarroll JA; Children's Cancer Institute, Lowy Cancer Research Centre, Randwick, University of New South Wales Australia, Sydney, New South Wales, Australia. ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australian Centre for NanoMedicine, University of New South Wales Australia, New So
  • Gan PP; Children's Cancer Institute, Lowy Cancer Research Centre, Randwick, University of New South Wales Australia, Sydney, New South Wales, Australia.
  • Erlich RB; Children's Cancer Institute, Lowy Cancer Research Centre, Randwick, University of New South Wales Australia, Sydney, New South Wales, Australia.
  • Liu M; Children's Cancer Institute, Lowy Cancer Research Centre, Randwick, University of New South Wales Australia, Sydney, New South Wales, Australia.
  • Dwarte T; Children's Cancer Institute, Lowy Cancer Research Centre, Randwick, University of New South Wales Australia, Sydney, New South Wales, Australia.
  • Sagnella SS; Children's Cancer Institute, Lowy Cancer Research Centre, Randwick, University of New South Wales Australia, Sydney, New South Wales, Australia. ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australian Centre for NanoMedicine, University of New South Wales Australia, New So
  • Akerfeldt MC; Children's Cancer Institute, Lowy Cancer Research Centre, Randwick, University of New South Wales Australia, Sydney, New South Wales, Australia.
  • Yang L; Children's Cancer Institute, Lowy Cancer Research Centre, Randwick, University of New South Wales Australia, Sydney, New South Wales, Australia.
  • Parker AL; Children's Cancer Institute, Lowy Cancer Research Centre, Randwick, University of New South Wales Australia, Sydney, New South Wales, Australia.
  • Chang MH; Children's Cancer Institute, Lowy Cancer Research Centre, Randwick, University of New South Wales Australia, Sydney, New South Wales, Australia.
  • Shum MS; Children's Cancer Institute, Lowy Cancer Research Centre, Randwick, University of New South Wales Australia, Sydney, New South Wales, Australia.
  • Byrne FL; Children's Cancer Institute, Lowy Cancer Research Centre, Randwick, University of New South Wales Australia, Sydney, New South Wales, Australia.
  • Kavallaris M; Children's Cancer Institute, Lowy Cancer Research Centre, Randwick, University of New South Wales Australia, Sydney, New South Wales, Australia. ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australian Centre for NanoMedicine, University of New South Wales Australia, New So
Cancer Res ; 75(2): 415-25, 2015 Jan 15.
Article en En | MEDLINE | ID: mdl-25414139
ABSTRACT
ßIII-tubulin (encoded by TUBB3) expression is associated with therapeutic resistance and aggressive disease in non-small cell lung cancer (NSCLC), but the basis for its pathogenic influence is not understood. Functional and differential proteomics revealed that ßIII-tubulin regulates expression of proteins associated with malignant growth and metastases. In particular, the adhesion-associated tumor suppressor maspin was differentially regulated by ßIII-tubulin. Functionally, ßIII-tubulin suppression altered cell morphology, reduced tumor spheroid outgrowth, and increased sensitivity to anoikis. Mechanistically, the PTEN/AKT signaling axis was defined as a critical pathway regulated by ßIII-tubulin in NSCLC cells. ßIII-Tubulin blockage in vivo reduced tumor incidence and growth. Overall, our findings revealed how ßIII-tubulin influences tumor growth in NSCLC, defining new biologic functions and mechanism of action of ßIII-tubulin in tumorigenesis.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tubulina (Proteína) / Carcinoma de Pulmón de Células no Pequeñas / Fosfohidrolasa PTEN / Proteínas Proto-Oncogénicas c-akt / Neoplasias Pulmonares Tipo de estudio: Guideline Límite: Animals / Humans Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tubulina (Proteína) / Carcinoma de Pulmón de Células no Pequeñas / Fosfohidrolasa PTEN / Proteínas Proto-Oncogénicas c-akt / Neoplasias Pulmonares Tipo de estudio: Guideline Límite: Animals / Humans Idioma: En Año: 2015 Tipo del documento: Article