Hormone replacement with 17ß-estradiol plus dihydrotestosterone restores male sexual behavior in rats treated neonatally with clomipramine.
Horm Behav
; 66(5): 820-7, 2014 Nov.
Article
en En
| MEDLINE
| ID: mdl-25449595
ABSTRACT
Male sexual behavior (MSB) in rodents, in both its consummatory and motivational components, is regulated by hormones such as testosterone, 17ß-estradiol and 5-α-dihydrotestosterone. In experiments, neonatal treatment with clomipramine (CMI; a serotonin reuptake inhibitor) reproduces some of the signs of depression in adult age, including reduced sexual behavior manifested in a lower percentage of subjects that mount, intromit and ejaculate, although their testosterone levels were not altered. However, the effect of this treatment on estrogen levels and the consequences of hormone substitution using 17ß-estradiol and 5-α-dihydrotestosterone on the expression of male sexual behavior are still unknown. Therefore, the objective of the present study was to analyze the effect of neonatal treatment with CMI on plasma testosterone and 17ß-estradiol levels, and the role of testosterone, 17ß-estradiol and 5-α-dihydrotestosterone in altering the consummatory and motivational components of sexual behavior in male rats. To this end, it analyzed the copulatory parameters and sexual incentive motivation (SIM) of rats treated with CMI under two conditions basal and post-hormone replacements. Neonatal treatment with CMI did not affect plasma testosterone or 17ß-estradiol concentrations, but did decrease both the consummatory component and sexual motivation according to the results of the SIM test. These aspects were recovered after administering 17ß-estradiol +5-α-dihydrotestosterone, but not testosterone.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Conducta Sexual
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Conducta Sexual Animal
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Dihidrotestosterona
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Clomipramina
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Estradiol
Límite:
Animals
Idioma:
En
Año:
2014
Tipo del documento:
Article