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Optogenetic fMRI reveals distinct, frequency-dependent networks recruited by dorsal and intermediate hippocampus stimulations.
Weitz, Andrew J; Fang, Zhongnan; Lee, Hyun Joo; Fisher, Robert S; Smith, Wesley C; Choy, ManKin; Liu, Jia; Lin, Peter; Rosenberg, Matthew; Lee, Jin Hyung.
  • Weitz AJ; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA.
  • Fang Z; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA; Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA.
  • Lee HJ; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA.
  • Fisher RS; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA.
  • Smith WC; Department of Neuroscience, University of California, Los Angeles, CA 90095, USA.
  • Choy M; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA.
  • Liu J; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA; Department of Neuroscience, University of California, Los Angeles, CA 90095, USA; Department of Electrical Engineering, University of California, Los Angeles, CA 90095, USA.
  • Lin P; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA.
  • Rosenberg M; Department of Electrical Engineering, University of California, Los Angeles, CA 90095, USA; Department of Psychology, University of California, Los Angeles, CA 90095, USA.
  • Lee JH; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA; Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA; Department of Neurosurgery, Stanford, CA 94
Neuroimage ; 107: 229-241, 2015 Feb 15.
Article en En | MEDLINE | ID: mdl-25462689
ABSTRACT
Although the connectivity of hippocampal circuits has been extensively studied, the way in which these connections give rise to large-scale dynamic network activity remains unknown. Here, we used optogenetic fMRI to visualize the brain network dynamics evoked by different frequencies of stimulation of two distinct neuronal populations within dorsal and intermediate hippocampus. Stimulation of excitatory cells in intermediate hippocampus caused widespread cortical and subcortical recruitment at high frequencies, whereas stimulation in dorsal hippocampus led to activity primarily restricted to hippocampus across all frequencies tested. Sustained hippocampal responses evoked during high-frequency stimulation of either location predicted seizure-like afterdischarges in video-EEG experiments, while the widespread activation evoked by high-frequency stimulation of intermediate hippocampus predicted behavioral seizures. A negative BOLD signal observed in dentate gyrus during dorsal, but not intermediate, hippocampus stimulation is proposed to underlie the mechanism for these differences. Collectively, our results provide insight into the dynamic function of hippocampal networks and their role in seizures.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Optogenética / Hipocampo / Red Nerviosa Límite: Animals Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Optogenética / Hipocampo / Red Nerviosa Límite: Animals Idioma: En Año: 2015 Tipo del documento: Article