Early depolarizing GABA controls critical-period plasticity in the rat visual cortex.
Nat Neurosci
; 18(1): 87-96, 2015 Jan.
Article
en En
| MEDLINE
| ID: mdl-25485756
ABSTRACT
Hyperpolarizing and inhibitory GABA regulates critical periods for plasticity in sensory cortices. Here we examine the role of early, depolarizing GABA in the control of plasticity mechanisms. We report that brief interference with depolarizing GABA during early development prolonged critical-period plasticity in visual cortical circuits without affecting the overall development of the visual system. The effects on plasticity were accompanied by dampened inhibitory neurotransmission, downregulation of brain-derived neurotrophic factor (BDNF) expression and reduced density of extracellular matrix perineuronal nets. Early interference with depolarizing GABA decreased perinatal BDNF signaling, and a pharmacological increase of BDNF signaling during GABA interference rescued the effects on plasticity and its regulators later in life. We conclude that depolarizing GABA exerts a long-lasting, selective modulation of plasticity of cortical circuits by a strong crosstalk with BDNF.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Corteza Visual
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Período Crítico Psicológico
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Ácido gamma-Aminobutírico
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Plasticidad Neuronal
Límite:
Animals
Idioma:
En
Año:
2015
Tipo del documento:
Article