Linezolid bladder irrigation as adjunctive treatment for a vancomycin-resistant Enterococcus faecium catheter-associated urinary tract infection.
Ann Pharmacother
; 49(2): 250-3, 2015 Feb.
Article
en En
| MEDLINE
| ID: mdl-25515867
ABSTRACT
OBJECTIVE:
To describe the first reported successful use of adjunctive linezolid bladder irrigation. CASESUMMARY:
An 89-year-old woman with 10% TBSA burns developed septic shock and anuric acute kidney insufficiency. She acquired a urinary tract infection caused by vancomycin-resistant Enterococcus faecium (VREfm). Based on clinical status, a linezolid bladder irrigation was initiated in addition to high-dose intravenous linezolid and demonstrated microbiological cure with 7 days of treatment.DISCUSSION:
Linezolid is primarily hepatically cleared and has no labeled indication for urinary tract infections. Anuria adds an additional complication of potentially reduced urinary drug concentrations. Bladder irrigation offers the benefit of achieving high local drug concentrations, but there are no data regarding such a route for linezolid. This case report is the first demonstrating the use, stability, safety, and efficacy of linezolid as a continuous bladder irrigation.CONCLUSIONS:
Linezolid use as a bladder irrigation may be a feasible route of administration in anuric, critically ill patients with VREfm and few antimicrobial options. Further studies are warranted.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Infecciones Urinarias
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Infección Hospitalaria
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Infecciones por Bacterias Grampositivas
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Oxazolidinonas
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Acetamidas
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Antibacterianos
Tipo de estudio:
Risk_factors_studies
Límite:
Aged80
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Female
/
Humans
Idioma:
En
Año:
2015
Tipo del documento:
Article