Briarane diterpenoids from the gorgonian Dichotella gemmacea.
Mar Drugs
; 12(12): 6178-89, 2014 Dec 18.
Article
en En
| MEDLINE
| ID: mdl-25528959
ABSTRACT
Seven new briarane diterpenoids, gemmacolides AS-AY (1-7), were isolated together with ten known analogues (8-17) from the South China Sea gorgonian Dichotella gemmacea. The structures of the new compounds were elucidated by the detailed analysis of spectroscopic data and comparison with reported data. The absolute configuration of compounds was determined based on electronic circular dichroism (ECD) experiments and genetic correlations as well. Compounds 15 and 16 were reported for the first time for the gorgonian. In the preliminary in vitro bioassays, compound 5 showed potential growth inhibitory activity against MG63 cells.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Antozoos
/
Diterpenos
Límite:
Animals
/
Humans
País como asunto:
Asia
Idioma:
En
Año:
2014
Tipo del documento:
Article