[Th1/2-balance shift during acute graft-versus-host reaction developing against the background of experimental hyperlipidemia].
Zh Mikrobiol Epidemiol Immunobiol
; (5): 70-7, 2014.
Article
en Ru
| MEDLINE
| ID: mdl-25536775
ABSTRACT
AIM:
Evaluate the effect of experimental hyperlipidemia on the intensity of development of acute graft-versus-host reaction (GVHR) in mice. MATERIALS ANDMETHODS:
Half-allogenic system C57Bl/6 (C57Bl/6 x DBA/2)F1 was used as a laboratory model of acute GVHR. Experimental hyperlipidemia in mice-recipients was induced by repeated administration of poloxamer 407.RESULTS:
Lethality in the group of mice with acute GVHR developing against the background of preceding hyperlipidemia was significantly higher (70% at day 50 of GVHR development) compared with control group with acute GVHR (50% lethality at day 50). Such effect on the degree of severity of acute GVHR induced under the conditions of hyperlipidemia is confirmed by a more pronounced destruction of thymus in mice of the group with previously induced hyperlipidemia.CONCLUSION:
Preceding hyperlipidemia induced by administration of poloxamer 407 shifts Th1/2- balance in the development of acute GVHR towards Th1. Mechanisms of this effect and possible role of nuclear LXR receptors in regulation of immune reactions are discussed.
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Banco de datos:
MEDLINE
Asunto principal:
Balance Th1 - Th2
/
Reacción Injerto-Huésped
/
Hiperlipidemias
Límite:
Animals
/
Humans
Idioma:
Ru
Año:
2014
Tipo del documento:
Article