Expression of cluster of differentiation-95 and relevant signaling molecules in liver cancer.
Mol Med Rep
; 11(5): 3375-81, 2015 May.
Article
en En
| MEDLINE
| ID: mdl-25543761
ABSTRACT
The present study investigated the protein expression levels of cluster of differentiation (CD)95, caspase8, caspase3 and poly(ADPribose) polymerase 1 (PARP1) in liver cancer and its association with clinical pathological parameters. The results demonstrated that the expression of CD95 correlated with histological differentiation, liver cirrhosis, lymph node metastasis and distant metastasis (P<0.05), however, no correlations with gender, age, quantity of tumor nodules or T stage were observed (P>0.05). The expression of CD95 was upregulated using a plasmid, which led to an increase in the expression levels of caspase8 and caspase3 and a decrease in the expression of PARP1. Upregulation of CD95 also promoted the apoptosis of the liver cancer cells. These results indicated that CD95 was associated with liver cancer and promoted the apoptosis of liver cancer cells by caspase8, caspase3 and PARP1.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Transducción de Señal
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Carcinoma Hepatocelular
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Receptor fas
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Neoplasias Hepáticas
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2015
Tipo del documento:
Article