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Highly specific ubiquitin-competing molecules effectively promote frataxin accumulation and partially rescue the aconitase defect in Friedreich ataxia cells.
Rufini, Alessandra; Cavallo, Francesca; Condò, Ivano; Fortuni, Silvia; De Martino, Gabriella; Incani, Ottaviano; Di Venere, Almerinda; Benini, Monica; Massaro, Damiano Sergio; Arcuri, Gaetano; Serio, Dario; Malisan, Florence; Testi, Roberto.
  • Rufini A; Laboratory of Signal Transduction, Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Via Montpellier 1, Rome 00133, Italy; Fratagene Therapeutics Ltd., 22 Northumberland Rd., Dublin, Ireland.
  • Cavallo F; Laboratory of Signal Transduction, Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Via Montpellier 1, Rome 00133, Italy.
  • Condò I; Laboratory of Signal Transduction, Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Via Montpellier 1, Rome 00133, Italy.
  • Fortuni S; Laboratory of Signal Transduction, Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Via Montpellier 1, Rome 00133, Italy; Fratagene Therapeutics Ltd., 22 Northumberland Rd., Dublin, Ireland.
  • De Martino G; Laboratory of Signal Transduction, Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Via Montpellier 1, Rome 00133, Italy.
  • Incani O; Laboratory of Signal Transduction, Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Via Montpellier 1, Rome 00133, Italy.
  • Di Venere A; Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata," Via Montpellier 1, Rome 00133, Italy.
  • Benini M; Laboratory of Signal Transduction, Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Via Montpellier 1, Rome 00133, Italy.
  • Massaro DS; Laboratory of Signal Transduction, Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Via Montpellier 1, Rome 00133, Italy.
  • Arcuri G; Laboratory of Signal Transduction, Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Via Montpellier 1, Rome 00133, Italy.
  • Serio D; Laboratory of Signal Transduction, Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Via Montpellier 1, Rome 00133, Italy.
  • Malisan F; Laboratory of Signal Transduction, Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Via Montpellier 1, Rome 00133, Italy.
  • Testi R; Laboratory of Signal Transduction, Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Via Montpellier 1, Rome 00133, Italy; Fratagene Therapeutics Ltd., 22 Northumberland Rd., Dublin, Ireland. Electronic address: roberto.testi@uniroma2.it.
Neurobiol Dis ; 75: 91-9, 2015 Mar.
Article en En | MEDLINE | ID: mdl-25549872
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Aconitato Hidratasa / Ataxia de Friedreich / Fármacos Neuroprotectores / Proteínas de Unión a Hierro Límite: Humans Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Aconitato Hidratasa / Ataxia de Friedreich / Fármacos Neuroprotectores / Proteínas de Unión a Hierro Límite: Humans Idioma: En Año: 2015 Tipo del documento: Article