The effect of species representation on the detection of positive selection in primate gene data sets.
Mol Biol Evol
; 32(4): 1091-6, 2015 Apr.
Article
en En
| MEDLINE
| ID: mdl-25556235
ABSTRACT
Over evolutionary time, both host- and virus-encoded genes have been continually selected to modify their interactions with one another. This has resulted in the rapid evolution of the specific codons that govern the physical interactions between host and virus proteins. Virologists have discovered that these evolutionary signatures, acquired in nature, can provide a shortcut in the functional dissection of host-virus interactions in the laboratory. However, the use of evolution studies in this way is complicated by the fact that many nonhuman primate species are endangered, and biomaterials are often difficult to acquire. Here, we assess how the species representation in primate gene data sets affects the detection of positive natural selection. Our results demonstrate how targeted primate sequencing projects could greatly enhance research in immunology, virology, and beyond.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Primates
/
Selección Genética
/
Virus
/
Evolución Molecular
/
Interacciones Huésped-Patógeno
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Año:
2015
Tipo del documento:
Article