Dual-action combination therapy enhances angiogenesis while reducing tumor growth and spread.
Cancer Cell
; 27(1): 123-37, 2015 Jan 12.
Article
en En
| MEDLINE
| ID: mdl-25584895
ABSTRACT
Increasing chemotherapy delivery to tumors, while enhancing drug uptake and reducing side effects, is a primary goal of cancer research. In mouse and human cancer models in vivo, we show that coadministration of low-dose Cilengitide and Verapamil increases tumor angiogenesis, leakiness, blood flow, and Gemcitabine delivery. This approach reduces tumor growth, metastasis, and minimizes side effects while extending survival. At a molecular level, this strategy alters Gemcitabine transporter and metabolizing enzyme expression levels, enhancing the potency of Gemcitabine within tumor cells in vivo and in vitro. Thus, the dual action of low-dose Cilengitide, in vessels and tumor cells, improves chemotherapy efficacy. Overall, our data demonstrate that vascular promotion therapy is a means to improve cancer treatment.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Pancreáticas
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Venenos de Serpiente
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Verapamilo
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Carcinoma Pulmonar de Lewis
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Desoxicitidina
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Antimetabolitos Antineoplásicos
Límite:
Animals
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Humans
Idioma:
En
Año:
2015
Tipo del documento:
Article