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Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C2-symmetric inhibitors with diyne and biphenyl linkers.
Giroux, Simon; Bilimoria, Darius; Cadilhac, Caroline; Cottrell, Kevin M; Denis, Francois; Dietrich, Evelyne; Ewing, Nigel; Henderson, James A; L'Heureux, Lucille; Mani, Nagraj; Morris, Mark; Nicolas, Olivier; Reddy, T Jagadeeswar; Selliah, Subajini; Shawgo, Rebecca S; Xu, Jinwang; Chauret, Nathalie; Berlioz-Seux, Francoise; Chan, Laval C; Das, Sanjoy K; Grillot, Anne-Laure; Bennani, Youssef L; Maxwell, John P.
  • Giroux S; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA.
  • Bilimoria D; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada.
  • Cadilhac C; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada.
  • Cottrell KM; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA.
  • Denis F; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada.
  • Dietrich E; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada.
  • Ewing N; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA.
  • Henderson JA; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA.
  • L'Heureux L; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada.
  • Mani N; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA.
  • Morris M; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA.
  • Nicolas O; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada.
  • Reddy TJ; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada.
  • Selliah S; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada.
  • Shawgo RS; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA.
  • Xu J; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA.
  • Chauret N; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada.
  • Berlioz-Seux F; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA.
  • Chan LC; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada.
  • Das SK; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada.
  • Grillot AL; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA.
  • Bennani YL; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA.
  • Maxwell JP; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA.
Bioorg Med Chem Lett ; 25(4): 936-9, 2015 Feb 15.
Article en En | MEDLINE | ID: mdl-25595681
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / Proteínas no Estructurales Virales / Descubrimiento de Drogas / Imidazoles Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / Proteínas no Estructurales Virales / Descubrimiento de Drogas / Imidazoles Idioma: En Año: 2015 Tipo del documento: Article