Ethanol exposure induces neonatal neurodegeneration by enhancing CB1R Exon1 histone H4K8 acetylation and up-regulating CB1R function causing neurobehavioral abnormalities in adult mice.

Subbanna, Shivakumar; Nagre, Nagaraja N; Umapathy, Nagavedi S; Pace, Betty S; Basavarajappa, Balapal S

Subbanna, Shivakumar; Nagre, Nagaraja N; Umapathy, Nagavedi S; Pace, Betty S; Basavarajappa, Balapal S.

Subbanna S; Division of Analytical Psychopharmacology, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY (Drs Subbanna, Nagre, and Basavarajappa); Vascular Biology Center, Georgia Regents University, Augusta, GA (Dr Umapathy); Department of Pediatrics, Georgia Regents University, Augusta, GA (Dr P
Nagre NN; Division of Analytical Psychopharmacology, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY (Drs Subbanna, Nagre, and Basavarajappa); Vascular Biology Center, Georgia Regents University, Augusta, GA (Dr Umapathy); Department of Pediatrics, Georgia Regents University, Augusta, GA (Dr P
Umapathy NS; Division of Analytical Psychopharmacology, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY (Drs Subbanna, Nagre, and Basavarajappa); Vascular Biology Center, Georgia Regents University, Augusta, GA (Dr Umapathy); Department of Pediatrics, Georgia Regents University, Augusta, GA (Dr P
Pace BS; Division of Analytical Psychopharmacology, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY (Drs Subbanna, Nagre, and Basavarajappa); Vascular Biology Center, Georgia Regents University, Augusta, GA (Dr Umapathy); Department of Pediatrics, Georgia Regents University, Augusta, GA (Dr P
Basavarajappa BS; Division of Analytical Psychopharmacology, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY (Drs Subbanna, Nagre, and Basavarajappa); Vascular Biology Center, Georgia Regents University, Augusta, GA (Dr Umapathy); Department of Pediatrics, Georgia Regents University, Augusta, GA (Dr P

Int J Neuropsychopharmacol ; 18(5)2014 Oct 31.

Article en En | MEDLINE | ID: mdl-25609594

Asunto(s)

Etanol/toxicidad; Regulación de la Expresión Génica/efectos de los fármacos; Trastornos de la Memoria/inducido químicamente; Enfermedades Neurodegenerativas/inducido químicamente; Receptor Cannabinoide CB1/efectos de los fármacos; Receptor Cannabinoide CB1/metabolismo; Complejo Relacionado con el SIDA/metabolismo; Acetilación/efectos de los fármacos; Factores de Edad; Animales; Animales Recién Nacidos/metabolismo; Animales Recién Nacidos/psicología; Proteína de Unión a CREB/metabolismo; Depresores del Sistema Nervioso Central/toxicidad; Epigénesis Genética/efectos de los fármacos; Exones/efectos de los fármacos; Femenino; Hipocampo/efectos de los fármacos; Hipocampo/metabolismo; Histonas/genética; Masculino; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Neocórtex/efectos de los fármacos; Neocórtex/metabolismo; Enfermedades Neurodegenerativas/metabolismo; Enfermedades Neurodegenerativas/psicología; Fosforilación/efectos de los fármacos; Receptor Cannabinoide CB1/deficiencia; Receptor Cannabinoide CB1/genética; Conducta Social; Regulación hacia Arriba/efectos de los fármacos

Palabras clave

FASD; cannabinoid receptor system; epigenetics; memory loss; synaptic signaling

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Enfermedades Neurodegenerativas / Receptor Cannabinoide CB1 / Etanol / Trastornos de la Memoria Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2014 Tipo del documento: Article

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