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Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia.
Konopleva, Marina; Thall, Peter F; Yi, Cecilia Arana; Borthakur, Gautam; Coveler, Andrew; Bueso-Ramos, Carlos; Benito, Juliana; Konoplev, Sergej; Gu, Yongchuan; Ravandi, Farhad; Jabbour, Elias; Faderl, Stefan; Thomas, Deborah; Cortes, Jorge; Kadia, Tapan; Kornblau, Steven; Daver, Naval; Pemmaraju, Naveen; Nguyen, Hoang Q; Feliu, Jennie; Lu, Hongbo; Wei, Caimiao; Wilson, William R; Melink, Teresa J; Gutheil, John C; Andreeff, Michael; Estey, Elihu H; Kantarjian, Hagop.
  • Konopleva M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA mkonople@mdanderson.org.
  • Thall PF; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Yi CA; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Borthakur G; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Coveler A; Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.
  • Bueso-Ramos C; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Benito J; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Konoplev S; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Gu Y; Auckland Cancer Society Research Centre, University of Auckland, NZ, USA.
  • Ravandi F; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Jabbour E; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Faderl S; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Thomas D; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Cortes J; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Kadia T; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Kornblau S; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Daver N; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Pemmaraju N; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Nguyen HQ; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Feliu J; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Lu H; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Wei C; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Wilson WR; Auckland Cancer Society Research Centre, University of Auckland, NZ, USA.
  • Melink TJ; Proacta Inc., La Jolla, CA, USA.
  • Gutheil JC; Proacta Inc., La Jolla, CA, USA.
  • Andreeff M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Estey EH; Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.
  • Kantarjian H; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Haematologica ; 100(7): 927-34, 2015 Jul.
Article en En | MEDLINE | ID: mdl-25682597
Asunto(s)
Antineoplásicos Alquilantes/administración & dosificación; Hipoxia/tratamiento farmacológico; Leucemia Mieloide Aguda/tratamiento farmacológico; Compuestos de Mostaza Nitrogenada/administración & dosificación; Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamiento farmacológico; Profármacos/administración & dosificación; Adulto; Anciano; Anemia/inducido químicamente; Anemia/genética; Anemia/metabolismo; Anemia/patología; Antígenos de Neoplasias/genética; Antígenos de Neoplasias/metabolismo; Antineoplásicos Alquilantes/efectos adversos; Antineoplásicos Alquilantes/metabolismo; Biomarcadores/metabolismo; Médula Ósea/efectos de los fármacos; Médula Ósea/metabolismo; Médula Ósea/patología; Anhidrasa Carbónica IX; Anhidrasas Carbónicas/genética; Anhidrasas Carbónicas/metabolismo; Enterocolitis/inducido químicamente; Enterocolitis/genética; Enterocolitis/metabolismo; Enterocolitis/patología; Femenino; Expresión Génica; Humanos; Hipoxia/complicaciones; Hipoxia/genética; Hipoxia/patología; Subunidad alfa del Factor 1 Inducible por Hipoxia/genética; Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo; Leucemia Mieloide Aguda/complicaciones; Leucemia Mieloide Aguda/genética; Leucemia Mieloide Aguda/patología; Masculino; Persona de Mediana Edad; Neutropenia/inducido químicamente; Neutropenia/genética; Neutropenia/metabolismo; Neutropenia/patología; Compuestos de Mostaza Nitrogenada/efectos adversos; Compuestos de Mostaza Nitrogenada/metabolismo; Nitroimidazoles/farmacología; Leucemia-Linfoma Linfoblástico de Células Precursoras/complicaciones; Leucemia-Linfoma Linfoblástico de Células Precursoras/genética; Leucemia-Linfoma Linfoblástico de Células Precursoras/patología; Profármacos/efectos adversos; Profármacos/metabolismo; Recurrencia; Inducción de Remisión; Trombocitopenia/inducido químicamente; Trombocitopenia/genética
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Profármacos / Leucemia Mieloide Aguda / Antineoplásicos Alquilantes / Leucemia-Linfoma Linfoblástico de Células Precursoras / Hipoxia / Compuestos de Mostaza Nitrogenada Tipo de estudio: Clinical_trials / Prognostic_studies Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
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XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Profármacos / Leucemia Mieloide Aguda / Antineoplásicos Alquilantes / Leucemia-Linfoma Linfoblástico de Células Precursoras / Hipoxia / Compuestos de Mostaza Nitrogenada Tipo de estudio: Clinical_trials / Prognostic_studies Idioma: En Año: 2015 Tipo del documento: Article