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Infertility and incident endometrial cancer risk: a pooled analysis from the epidemiology of endometrial cancer consortium (E2C2).
Yang, H P; Cook, L S; Weiderpass, E; Adami, H-O; Anderson, K E; Cai, H; Cerhan, J R; Clendenen, T V; Felix, A S; Friedenreich, C M; Garcia-Closas, M; Goodman, M T; Liang, X; Lissowska, J; Lu, L; Magliocco, A M; McCann, S E; Moysich, K B; Olson, S H; Petruzella, S; Pike, M C; Polidoro, S; Ricceri, F; Risch, H A; Sacerdote, C; Setiawan, V W; Shu, X O; Spurdle, A B; Trabert, B; Webb, P M; Wentzensen, N; Xiang, Y-B; Xu, Y; Yu, H; Zeleniuch-Jacquotte, A; Brinton, L A.
  • Yang HP; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Cook LS; University of New Mexico, Albuquerque, NM 87131, USA.
  • Weiderpass E; 1] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-171 77 Stockholm, Sweden [2] Department of Genetic Epidemiology, Folkhälsan Research Center, 00014 Helsinki, Finland [3] Department of Research, Cancer Registry of Norway, N-0304 Oslo, Norway [4] Department of Communi
  • Adami HO; 1] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-171 77 Stockholm, Sweden [2] Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
  • Anderson KE; School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA.
  • Cai H; Department of Medicine, Division of Epidemiology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Cerhan JR; Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
  • Clendenen TV; Department of Population Health and NYU Perimutter Cancer Center, New York University School of Medicine, New York, NY 10016, USA.
  • Felix AS; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Friedenreich CM; Alberta Health Services, Calgary, Alberta T2T 5C7, Canada.
  • Garcia-Closas M; Institute of Cancer Research, Surrey SM2 5NG, UK.
  • Goodman MT; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  • Liang X; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Lissowska J; M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, 02-781 Warsaw, Poland.
  • Lu L; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT 06510, USA.
  • Magliocco AM; H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL33612, USA.
  • McCann SE; Roswell Park Cancer Institute, Buffalo, NY 14203, USA.
  • Moysich KB; Roswell Park Cancer Institute, Buffalo, NY 14203, USA.
  • Olson SH; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Petruzella S; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Pike MC; 1] Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA [2] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
  • Polidoro S; Human Genetics Foundation, 10126 Turin, Italy.
  • Ricceri F; Human Genetics Foundation, 10126 Turin, Italy.
  • Risch HA; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT 06510, USA.
  • Sacerdote C; 1] Human Genetics Foundation, 10126 Turin, Italy [2] Unit of Cancer Epidemiology, University of Turin and Center for Cancer Prevention, 10124 Turin, Italy.
  • Setiawan VW; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
  • Shu XO; Department of Medicine, Division of Epidemiology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Spurdle AB; QIMR Berghofer Medical Research Institute, Herston, Queensland 4029, Australia.
  • Trabert B; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Webb PM; QIMR Berghofer Medical Research Institute, Herston, Queensland 4029, Australia.
  • Wentzensen N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Xiang YB; Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Xu Y; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Yu H; University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
  • Zeleniuch-Jacquotte A; Department of Population Health and NYU Perimutter Cancer Center, New York University School of Medicine, New York, NY 10016, USA.
  • Brinton LA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
Br J Cancer ; 112(5): 925-33, 2015 Mar 03.
Article en En | MEDLINE | ID: mdl-25688738
ABSTRACT

BACKGROUND:

Nulliparity is an endometrial cancer risk factor, but whether or not this association is due to infertility is unclear. Although there are many underlying infertility causes, few studies have assessed risk relations by specific causes.

METHODS:

We conducted a pooled analysis of 8153 cases and 11 713 controls from 2 cohort and 12 case-control studies. All studies provided self-reported infertility and its causes, except for one study that relied on data from national registries. Logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI).

RESULTS:

Nulliparous women had an elevated endometrial cancer risk compared with parous women, even after adjusting for infertility (OR=1.76; 95% CI 1.59-1.94). Women who reported infertility had an increased risk compared with those without infertility concerns, even after adjusting for nulliparity (OR=1.22; 95% CI 1.13-1.33). Among women who reported infertility, none of the individual infertility causes were substantially related to endometrial cancer.

CONCLUSIONS:

Based on mainly self-reported infertility data that used study-specific definitions of infertility, nulliparity and infertility appeared to independently contribute to endometrial cancer risk. Understanding residual endometrial cancer risk related to infertility, its causes and its treatments may benefit from large studies involving detailed data on various infertility parameters.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Endometriales / Infertilidad Femenina Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
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PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Endometriales / Infertilidad Femenina Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Año: 2015 Tipo del documento: Article