Single-cell analysis challenges the connection between autophagy and senescence induced by DNA damage.
Autophagy
; 11(7): 1099-113, 2015.
Article
en En
| MEDLINE
| ID: mdl-25701485
Palabras clave
3MA, 3-methyladenine; AMP-activated; AO, acridine orange; BafA1, bafilomycin A1; CDKN1A/p21, cyclin-dependent kinase inhibitor 1A (p21 Cip1); CPD, cumulative population doubling; DDR, DNA damage response; DFM, drug-free medium; DNA damage; H2AFX, H2A histone family; MAP1LC3A/LC3, microtubule-associated protein 1 light chain 3 α; MTOR, mechanistic target of rapamycin; MTORC1, MTOR complex 1; NA, nuclear area; NMA, nuclear morphometric analysis; PRKAA/AMPKα, protein kinase; RAPA, rapamycin; RPTOR/RAPTOR, regulatory-associated protein of MTOR; SA-ß-gal, senescence associated ß-galactosidase assay; SQSTM1/p62, sequestosome 1; TMZ, temozolomide; autophagy; cP1-4, cellular population 1 to 4; complex 1; member X; nP15, nuclear population 1 to 5; senescence; single cell; temozolomide
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Autofagia
/
Daño del ADN
/
Senescencia Celular
/
Análisis de la Célula Individual
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Año:
2015
Tipo del documento:
Article