Electrical impedance myography in Duchenne muscular dystrophy and healthy controls: A multicenter study of reliability and validity.
Muscle Nerve
; 52(4): 592-7, 2015 Oct.
Article
en En
| MEDLINE
| ID: mdl-25702806
ABSTRACT
INTRODUCTION:
Electrical impedance myography (EIM) is a non-invasive, painless, objective technique to quantify muscle pathology.METHODS:
We measured EIM in 8 arm and leg muscles in 61 boys with Duchenne muscular dystrophy (DMD) and 31 healthy boys, ages 3-12 years, at 5 centers. We determined the reliability of EIM and compared results in boys with DMD to controls and to 6-minute walk distance (6MWD), North Star Ambulatory Assessment (NSAA), timed functional tests (TFTs), and strength (hand-held dynamometry).RESULTS:
EIM was well tolerated and had good inter- and intrarater reliability (intraclass correlation coefficient 0.81-0.96). The averaged EIM phase value from all muscles was higher (P < 0.001) in controls (10.45 ± 2.29) than boys with DMD (7.31 ± 2.23), and correlated (P ≤ 0.001) with 6MWD (r = 0.55), NSAA (r = 0.66), TFTs (r = -0.56), and strength (r = 0.44).CONCLUSION:
EIM is a reliable and valid measure of disease severity in DMD. Longitudinal studies comparing EIM with other assessments over time in DMD are warranted.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Impedancia Eléctrica
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Músculo Esquelético
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Distrofia Muscular de Duchenne
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Fuerza Muscular
Tipo de estudio:
Clinical_trials
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Observational_studies
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Prognostic_studies
Límite:
Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Año:
2015
Tipo del documento:
Article