T cells and adaptive immunity to Mycobacterium tuberculosis in humans.
Immunol Rev
; 264(1): 74-87, 2015 Mar.
Article
en En
| MEDLINE
| ID: mdl-25703553
ABSTRACT
The adaptive immune response mediated by T cells is critical for control of Mycobacterium tuberculosis (M. tuberculosis) infection in humans. However, the M. tuberculosis antigens and host T-cell responses that are required for an effective adaptive immune response to M. tuberculosis infection are yet to be defined. Here, we review recent findings on CD4(+) and CD8(+) T-cell responses to M. tuberculosis infection and examine the roles of distinct M. tuberculosis-specific T-cell subsets in control of de novo and latent M. tuberculosis infection, and in the evolution of T-cell immunity to M. tuberculosis in response to tuberculosis treatment. In addition, we discuss recent studies that elucidate aspects of M. tuberculosis-specific adaptive immunity during human immunodeficiency virus co-infection and summarize recent findings from vaccine trials that provide insight into effective adaptive immune responses to M. tuberculosis infection.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tuberculosis
/
Subgrupos de Linfocitos T
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Interacciones Huésped-Patógeno
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Inmunidad Adaptativa
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Mycobacterium tuberculosis
Límite:
Humans
Idioma:
En
Año:
2015
Tipo del documento:
Article