Analysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function.

Jiang, Dadi; LaGory, Edward L; Kenzelmann Broz, Daniela; Bieging, Kathryn T; Brady, Colleen A; Link, Nichole; Abrams, John M; Giaccia, Amato J; Attardi, Laura D

Jiang, Dadi; LaGory, Edward L; Kenzelmann Broz, Daniela; Bieging, Kathryn T; Brady, Colleen A; Link, Nichole; Abrams, John M; Giaccia, Amato J; Attardi, Laura D.

Jiang D; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
LaGory EL; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Kenzelmann Broz D; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Bieging KT; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Brady CA; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Link N; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Abrams JM; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Giaccia AJ; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Attardi LD; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: attardi@stanford.edu.

Cell Rep ; 10(7): 1096-109, 2015 Feb 24.

Article en En | MEDLINE | ID: mdl-25704813

Asunto(s)

Acil-CoA Deshidrogenasa/metabolismo; Proteína p53 Supresora de Tumor/metabolismo; Acil-CoA Deshidrogenasa/genética; Secuencia de Aminoácidos; Sustitución de Aminoácidos; Animales; Línea Celular Tumoral; Supervivencia Celular/efectos de los fármacos; Redes Reguladoras de Genes; Glucosa/farmacología; Humanos; Ratones; Ratones Desnudos; Datos de Secuencia Molecular; Neoplasias/metabolismo; Neoplasias/patología; Fosforilación Oxidativa/efectos de los fármacos; Estructura Terciaria de Proteína; Interferencia de ARN; Alineación de Secuencia; Estrés Fisiológico; Activación Transcripcional; Trasplante Heterólogo; Proteína p53 Supresora de Tumor/antagonistas & inhibidores; Proteína p53 Supresora de Tumor/genética

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteína p53 Supresora de Tumor / Acil-CoA Deshidrogenasa Límite: Animals / Humans Idioma: En Año: 2015 Tipo del documento: Article

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