Targeted lung cancer therapy: preparation and optimization of transferrin-decorated nanostructured lipid carriers as novel nanomedicine for co-delivery of anticancer drugs and DNA.

Shao, Zhenyu; Shao, Jingyu; Tan, Bingxu; Guan, Shanghui; Liu, Zhulong; Zhao, Zengjun; He, Fangfang; Zhao, Jian

Shao, Zhenyu; Shao, Jingyu; Tan, Bingxu; Guan, Shanghui; Liu, Zhulong; Zhao, Zengjun; He, Fangfang; Zhao, Jian.

Shao Z; Department of Radiotherapy, Cancer Centre, Qilu Hospital, Shandong University, Ji'nan, Shandong, People's Republic of China.
Shao J; Affiliated Hospital of Northwest Institute of Mechanical and Electrical Engineering, Xianyang, Shaanxi, People's Republic of China.
Tan B; Department of Radiotherapy, Cancer Centre, Qilu Hospital, Shandong University, Ji'nan, Shandong, People's Republic of China.
Guan S; Department of Radiotherapy, Cancer Centre, Qilu Hospital, Shandong University, Ji'nan, Shandong, People's Republic of China.
Liu Z; Department of Radiotherapy, Cancer Centre, Qilu Hospital, Shandong University, Ji'nan, Shandong, People's Republic of China.
Zhao Z; Department of Radiotherapy, Cancer Centre, Qilu Hospital, Shandong University, Ji'nan, Shandong, People's Republic of China.
He F; Department of Radiotherapy, Cancer Centre, Qilu Hospital, Shandong University, Ji'nan, Shandong, People's Republic of China.
Zhao J; Department of Thoracic Surgery, Qilu Hospital, Shandong University, Ji'nan, Shandong, People's Republic of China.

Int J Nanomedicine ; 10: 1223-33, 2015.

Article en En | MEDLINE | ID: mdl-25709444

Asunto(s)

Antineoplásicos; Lípidos; Neoplasias Pulmonares/tratamiento farmacológico; Nanomedicina/métodos; Nanoestructuras; Transfección/métodos; Transferrina; Animales; Antineoplásicos/química; Antineoplásicos/metabolismo; Antineoplásicos/uso terapéutico; Antineoplásicos/toxicidad; Línea Celular Tumoral; ADN/genética; ADN/metabolismo; ADN/uso terapéutico; ADN/toxicidad; Portadores de Fármacos/química; Portadores de Fármacos/metabolismo; Portadores de Fármacos/uso terapéutico; Portadores de Fármacos/toxicidad; Proteínas Fluorescentes Verdes/genética; Proteínas Fluorescentes Verdes/metabolismo; Humanos; Lípidos/química; Lípidos/uso terapéutico; Lípidos/toxicidad; Ratones; Nanoestructuras/química; Nanoestructuras/uso terapéutico; Nanoestructuras/toxicidad; Paclitaxel/química; Paclitaxel/metabolismo; Paclitaxel/uso terapéutico; Paclitaxel/toxicidad; Transferrina/química; Transferrina/metabolismo; Transferrina/uso terapéutico; Transferrina/toxicidad; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

active targeting systems; co-delivery; nanostructured lipid carriers; paclitaxel; transferrin decoration

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transferrina / Transfección / Nanoestructuras / Nanomedicina / Lípidos / Neoplasias Pulmonares / Antineoplásicos Idioma: En Año: 2015 Tipo del documento: Article

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