Follow-up nerve conduction studies in CIDP after treatment with IGIV-C: Comparison of patients with and without subsequent relapse.
Muscle Nerve
; 52(4): 498-502, 2015 Oct.
Article
en En
| MEDLINE
| ID: mdl-25728021
ABSTRACT
INTRODUCTION:
Electrodiagnostic studies (EDX) are not performed routinely before treatment suspension in CIDP, and no data exist regarding their value in predicting clinical relapse.METHODS:
Serial EDX (baseline and after IGIV-C therapy) were analyzed from subjects in the ICE clinical trial who responded to IGIV-C treatment and were subsequently re-randomized to placebo in an extension phase. Comparisons were made between subjects who relapsed and those who did not.RESULTS:
A total of 55% (6/11) of the Relapse group had an increase in total number of demyelinating findings (DF) versus 8% (1/13) in the No Relapse group (P = 0.023). In the Relapse group, 100% had ≥ 1 new DF and 73% (8/11) had ≥ 4 new DF versus 60% (8/13) and 8% (1/13), respectively, in the No Relapse group.CONCLUSIONS:
An increased total number of DF or the occurrence of ≥ 4 new DF may indicate a higher risk of clinical relapse after treatment cessation in IGIV-C-responsive patients.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Resultado del Tratamiento
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Inmunoglobulinas Intravenosas
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Polirradiculoneuropatía Crónica Inflamatoria Desmielinizante
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Factores Inmunológicos
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Conducción Nerviosa
Tipo de estudio:
Clinical_trials
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2015
Tipo del documento:
Article