Putative neuropathological interactions in MSA: focus in the rostral ventrolateral medulla.
Clin Auton Res
; 25(1): 77-80, 2015 Feb.
Article
en En
| MEDLINE
| ID: mdl-25739472
ABSTRACT
We used double immunocytochemistry for α-synuclein and markers of sympathoexcitatory neurons, oligodendrocytes, iron metabolism, and autophagy to study putative neuropathological interactions in multiple system atrophy. We focused in the rostral ventrolateral medulla as a prototype vulnerable region. We found that loss of C1 neurons and oligodendrocytes related to glial cytoplasmic inclusion accumulation, downregulation of iron transport, and upregulation of autophagy and ferritin expression in these area.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tronco Encefálico
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Atrofia de Múltiples Sistemas
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Animals
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2015
Tipo del documento:
Article