Schisandrin B protects PC12 cells against oxidative stress of neurodegenerative diseases.
Neuroreport
; 26(6): 360-6, 2015 Apr 15.
Article
en En
| MEDLINE
| ID: mdl-25756908
ABSTRACT
Increasing evidence places Schisandrin B (Sch B) at an important position in nerve protection, indicating that Sch B might play a positive role in the therapy of neurodegenerative diseases. However, there is little information on it. Our studies showed that pretreatment with Sch B could reduce lactate dehydrogenase, malondialdehyde, and reactive oxygen species release and significantly increase the cell viability and the superoxide dismutase level. Sch B (10 µM) markedly inhibited cell apoptosis, whereas LY294002 (20 µM), a phosphatidylinositol-3 kinase inhibitor, blocked the antiapoptotic effect. More importantly, Sch B (10 µM) increased the phosphoprotein kinase B/protein kinase B (Akt) and B-cell lymphoma-2/Bcl-2 associated X protein ratios on preincubation with cells for 2 h, which was then inhibited by LY294002 (20 µM). Results indicate that Sch B can protect PC12 cells from apoptosis by activating the phosphatidylinositol-3 kinase/Akt signaling pathway and may emerge as a potential drug for neurodegenerative diseases.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Compuestos Policíclicos
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Apoptosis
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Lignanos
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Estrés Oxidativo
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Enfermedades Neurodegenerativas
Límite:
Animals
Idioma:
En
Año:
2015
Tipo del documento:
Article