Meroterpenoids and a naphthoquinone from Arnebia euchroma and their cytotoxic activity.
Planta Med
; 81(4): 320-6, 2015 Mar.
Article
en En
| MEDLINE
| ID: mdl-25760383
ABSTRACT
Four new meroterpenoids, arnebinols A-D (1-4), and one new prenylated naphthoquinone, 5,8-O-dimethyl-11-deoxyalkannin (5), together with seven known meroterpenoids (6-12) were isolated from the roots of Arnebia euchroma. The structures of the isolated compounds were elucidated unambiguously by spectroscopic data analysis, as well as X-ray-single crystal diffraction analysis. Arnebinol A (1) and B (2) are rare meroterpenoids possessing a 6/10/5 tricyclic ring system. Compounds 1-12 were evaluated for their cytotoxicities against MG-63 and SNU387 human cancer cell lines. Compound 5 exhibited the most potent activity with IC50 values of 2.69 µM and 6.08 µM, respectively.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
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Boraginaceae
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Monoterpenos
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Fitoterapia
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Neoplasias
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Antineoplásicos Fitogénicos
Límite:
Humans
Idioma:
En
Año:
2015
Tipo del documento:
Article