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Simultaneous Identification of Multiple ß-Lactamases in Acinetobacter baumannii in Relation to Carbapenem and Ceftazidime Resistance, Using Liquid Chromatography-Tandem Mass Spectrometry.
Trip, Hein; Mende, Katrin; Majchrzykiewicz-Koehorst, Joanna A; Sedee, Norbert J A; Hulst, Albert G; Jansen, Hugo-Jan; Murray, Clinton K; Paauw, Armand.
  • Trip H; Department of Earth, Life, and Social Sciences, TNO, Rijswijk, The Netherlands hein.trip@tno.nl.
  • Mende K; Department of Medicine, San Antonio Military Medical Center, Joint Base San Antonio-Fort Sam Houston, San Antonio, Texas, USA.
  • Majchrzykiewicz-Koehorst JA; Department of Earth, Life, and Social Sciences, TNO, Rijswijk, The Netherlands.
  • Sedee NJ; Department of Earth, Life, and Social Sciences, TNO, Rijswijk, The Netherlands.
  • Hulst AG; Department of Earth, Life, and Social Sciences, TNO, Rijswijk, The Netherlands.
  • Jansen HJ; Expert Centre Force Health Protection, Ministry of Defence, Doorn, The Netherlands.
  • Murray CK; Department of Medicine, San Antonio Military Medical Center, Joint Base San Antonio-Fort Sam Houston, San Antonio, Texas, USA.
  • Paauw A; Department of Earth, Life, and Social Sciences, TNO, Rijswijk, The Netherlands.
J Clin Microbiol ; 53(6): 1927-30, 2015 Jun.
Article en En | MEDLINE | ID: mdl-25788550
Shotgun proteomics using liquid chromatography-tandem mass spectrometry (LC-MS/MS) was applied to detect ß-lactamases in clinical Acinetobacter baumannii isolates. The correlation of the detection of ß-lactamase proteins (rather than PCR detection of the corresponding genes) with the resistance phenotypes demonstrated an added value for LC-MS/MS in antimicrobial susceptibility testing.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Beta-Lactamasas / Carbapenémicos / Ceftazidima / Farmacorresistencia Bacteriana Múltiple / Acinetobacter baumannii Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Año: 2015 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Beta-Lactamasas / Carbapenémicos / Ceftazidima / Farmacorresistencia Bacteriana Múltiple / Acinetobacter baumannii Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Año: 2015 Tipo del documento: Article