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Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution.
Kovac, Michal; Navas, Carolina; Horswell, Stuart; Salm, Max; Bardella, Chiara; Rowan, Andrew; Stares, Mark; Castro-Giner, Francesc; Fisher, Rosalie; de Bruin, Elza C; Kovacova, Monika; Gorman, Maggie; Makino, Seiko; Williams, Jennet; Jaeger, Emma; Jones, Angela; Howarth, Kimberley; Larkin, James; Pickering, Lisa; Gore, Martin; Nicol, David L; Hazell, Steven; Stamp, Gordon; O'Brien, Tim; Challacombe, Ben; Matthews, Nik; Phillimore, Benjamin; Begum, Sharmin; Rabinowitz, Adam; Varela, Ignacio; Chandra, Ashish; Horsfield, Catherine; Polson, Alexander; Tran, Maxine; Bhatt, Rupesh; Terracciano, Luigi; Eppenberger-Castori, Serenella; Protheroe, Andrew; Maher, Eamonn; El Bahrawy, Mona; Fleming, Stewart; Ratcliffe, Peter; Heinimann, Karl; Swanton, Charles; Tomlinson, Ian.
  • Kovac M; 1] Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK [2] Department of Biomedicine, Research Group Human Genomics, University of Basel, Mattenstrasse 28, 4058 Bas
  • Navas C; Translational Cancer Therapeutics Laboratory, London Research Institute, Cancer Research UK, 44, Lincoln's Inn Fields, London WC2A 3LY, UK.
  • Horswell S; Bioinformatics and Biostatistics, London Research Institute, Cancer Research UK, 44, Lincoln's Inn Fields, London WC2A 3LY, UK.
  • Salm M; Bioinformatics and Biostatistics, London Research Institute, Cancer Research UK, 44, Lincoln's Inn Fields, London WC2A 3LY, UK.
  • Bardella C; Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
  • Rowan A; Translational Cancer Therapeutics Laboratory, London Research Institute, Cancer Research UK, 44, Lincoln's Inn Fields, London WC2A 3LY, UK.
  • Stares M; Translational Cancer Therapeutics Laboratory, London Research Institute, Cancer Research UK, 44, Lincoln's Inn Fields, London WC2A 3LY, UK.
  • Castro-Giner F; Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
  • Fisher R; Translational Cancer Therapeutics Laboratory, London Research Institute, Cancer Research UK, 44, Lincoln's Inn Fields, London WC2A 3LY, UK.
  • de Bruin EC; University College London Cancer Institute and Hospitals, Huntley Street, London WC1E 6DD, UK.
  • Kovacova M; Faculty of Mechanical Engineering, Institute of Mathematics and Physics, Slovak University of Technology, Namestie slobody 17, 812 31 Bratislava, Slovakia.
  • Gorman M; Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
  • Makino S; Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
  • Williams J; Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
  • Jaeger E; Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
  • Jones A; Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
  • Howarth K; Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
  • Larkin J; Department of Medicine, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, London SW3 6JJ, UK.
  • Pickering L; Department of Medicine, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, London SW3 6JJ, UK.
  • Gore M; Department of Medicine, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, London SW3 6JJ, UK.
  • Nicol DL; 1] Department of Urology, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, London SW3 6JJ, UK [2] School of Medicine, University of Queensland, Brisbane, Australia.
  • Hazell S; Department of Histopathology, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, London SW3 6JJ, UK.
  • Stamp G; Experimental Histopathology, London Research Institute, Cancer Research UK, 44, Lincoln's Inn Fields, London WC2A 3LY, UK.
  • O'Brien T; Urology Centre, Guy's and St Thomas's Hospital NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK.
  • Challacombe B; Urology Centre, Guy's and St Thomas's Hospital NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK.
  • Matthews N; Advanced Sequencing Laboratory, London Research Institute, Cancer Research UK, 44, Lincoln's Inn Fields, London WC2A 3LY, UK.
  • Phillimore B; Advanced Sequencing Laboratory, London Research Institute, Cancer Research UK, 44, Lincoln's Inn Fields, London WC2A 3LY, UK.
  • Begum S; Advanced Sequencing Laboratory, London Research Institute, Cancer Research UK, 44, Lincoln's Inn Fields, London WC2A 3LY, UK.
  • Rabinowitz A; Advanced Sequencing Laboratory, London Research Institute, Cancer Research UK, 44, Lincoln's Inn Fields, London WC2A 3LY, UK.
  • Varela I; Genomic analysis of tumour development, Instituto de Biomedicina y Biotecnología de Cantabria (CSIC-UC-Sodercan), Departamento de Biología Molecular, Universidad de Cantabria, 39011 Santander, Spain.
  • Chandra A; Department of Histopathology, Guy's and St Thomas's Hospital NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK.
  • Horsfield C; Department of Histopathology, Guy's and St Thomas's Hospital NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK.
  • Polson A; Department of Histopathology, Guy's and St Thomas's Hospital NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK.
  • Tran M; Department of Oncology, Uro-Oncology Research Group, University of Cambridge, Cambridge CB2 0RE, UK.
  • Bhatt R; Department of Urology, University Hospitals, Birmingham B15 2TH, UK.
  • Terracciano L; Institute for Pathology, University Hospital Basel, Schönbeinstrasse 40, 4003 Basel, Switzerland.
  • Eppenberger-Castori S; Institute for Pathology, University Hospital Basel, Schönbeinstrasse 40, 4003 Basel, Switzerland.
  • Protheroe A; Department of Oncology, Cancer and Haematology Centre, Churchill Hospital, Oxford University Hospitals, Oxford OX3 7LJ, UK.
  • Maher E; Department of Medical Genetics, University of Cambridge, Cambridge CB2 0QQ, UK.
  • El Bahrawy M; Department of Histopathology, Imperial College London, Hammersmith Hospital, London W12 0HS, UK.
  • Fleming S; Department of Histopathology, Medical Research Institute, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, UK.
  • Ratcliffe P; Hypoxia Biology Laboratory, Henry Wellcome Building for Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
  • Heinimann K; Department of Biomedicine, Research Group Human Genomics, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.
  • Swanton C; 1] Translational Cancer Therapeutics Laboratory, London Research Institute, Cancer Research UK, 44, Lincoln's Inn Fields, London WC2A 3LY, UK [2] University College London Cancer Institute and Hospitals, Huntley Street, London WC1E 6DD, UK.
  • Tomlinson I; 1] Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK [2] NIHR Comprehensive Biomedical Research Centre, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Nat Commun ; 6: 6336, 2015 Mar 19.
Article en En | MEDLINE | ID: mdl-25790038
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Cromosomas / Neoplasias Renales / Mutación Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2015 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Cromosomas / Neoplasias Renales / Mutación Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2015 Tipo del documento: Article