Vitamin A-deficient diet accelerated atherogenesis in apolipoprotein E(-/-) mice and dietary ß-carotene prevents this consequence.
Biomed Res Int
; 2015: 758723, 2015.
Article
en En
| MEDLINE
| ID: mdl-25802864
ABSTRACT
Vitamin A is involved in regulation of glucose concentrations, lipid metabolism, and inflammation, which are major risk factors for atherogenesis. However, the effect of vitamin A deficiency on atherogenesis has not been investigated. Therefore, the objective of the current study was to examine whether vitamin A deficiency accelerates atherogenesis in apolipoprotein E-deficient mice (apoE(-/-)). ApoE(-/-) mice were allocated into the following groups control, fed vitamin A-containing chow diet; BC, fed chow diet fortified with Dunaliella powder containing ßc isomers; VAD, fed vitamin A-deficient diet; and VAD-BC group, fed vitamin A-deficient diet fortified with a Dunaliella powder. Following 15 weeks of treatment, liver retinol concentration had decreased significantly in the VAD group to about 30% that of control group. Vitamin A-deficient diet significantly increased both plasma cholesterol concentrations and the atherosclerotic lesion area at the aortic sinus (+61%) compared to the control group. Dietary ßc fortification inhibited the elevation in plasma cholesterol and retarded atherogenesis in mice fed the vitamin A-deficient diet. The results imply that dietary vitamin A deficiency should be examined as a risk factor for atherosclerosis and that dietary ßc, as a sole source of retinoids, can compensate for vitamin A deficiency.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Apolipoproteínas E
/
Vitamina A
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Deficiencia de Vitamina A
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Beta Caroteno
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Suplementos Dietéticos
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Aterosclerosis
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Año:
2015
Tipo del documento:
Article