Anti-inflammatory effect of Streptochlorin via TRIF-dependent signaling pathways in cellular and mouse models.
Int J Mol Sci
; 16(4): 6902-10, 2015 Mar 26.
Article
en En
| MEDLINE
| ID: mdl-25822875
ABSTRACT
Streptochlorin, a small compound derived from marine actinomycete, has been shown to have anti-angiogenic, anti-tumor, and anti-allergic activities. However, the anti-inflammatory effects and underlying mechanisms have not yet been reported. In the present study, we investigated the effect of streptochlorin on lipopolysaccharide (LPS)-induced inflammatory responses in vitro and in vivo. Streptochlorin attenuated the production of proinflammatory mediators such as nitric oxide, cyclooxygenase-2, pro-interleukin (IL)-1ß, and IL-6 in LPS-stimulated RAW264.7 cells through inhibition of the Toll/interleukin-1 receptor (TIR)-domain-containing adapter-inducing interferon-ß (TRIF)-dependent signaling pathway. Furthermore, streptochlorin suppressed the infiltration of immune cells such as neutrophils into the lung and proinflammatory cytokine production such as IL-6 and TNF-α in broncho-alveolar lavage fluid (BALF) in the LPS-induced acute lung injury (ALI) mouse model. Streptochlorin has potent anti-inflammatory effects through regulating TRIF-dependent signaling pathways, suggesting that streptochlorin may provide a valuable therapeutic strategy in treating various inflammatory diseases.
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Banco de datos:
MEDLINE
Asunto principal:
Oxazoles
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Transducción de Señal
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Lesión Pulmonar Aguda
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Indoles
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Macrófagos
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Antiinflamatorios
Límite:
Animals
Idioma:
En
Año:
2015
Tipo del documento:
Article