A pentose bisphosphate pathway for nucleoside degradation in Archaea.
Nat Chem Biol
; 11(5): 355-60, 2015 May.
Article
en En
| MEDLINE
| ID: mdl-25822915
ABSTRACT
Owing to the absence of the pentose phosphate pathway, the degradation pathway for the ribose moieties of nucleosides is unknown in Archaea. Here, in the archaeon Thermococcus kodakarensis, we identified a metabolic network that links the pentose moieties of nucleosides or nucleotides to central carbon metabolism. The network consists of three nucleoside phosphorylases, an ADP-dependent ribose-1-phosphate kinase and two enzymes of a previously identified NMP degradation pathway, ribose-1,5-bisphosphate isomerase and type III ribulose-1,5-bisphosphate carboxylase/oxygenase. Ribose 1,5-bisphosphate and ribulose 1,5-bisphosphate are intermediates of this pathway, which is thus designated the pentose bisphosphate pathway.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Vía de Pentosa Fosfato
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Ribulosa-Bifosfato Carboxilasa
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Archaea
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Thermococcus
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Nucleósidos
Idioma:
En
Año:
2015
Tipo del documento:
Article