Predicting and treating stress-induced vulnerability to epilepsy and depression.
Ann Neurol
; 78(1): 128-36, 2015 Jul.
Article
en En
| MEDLINE
| ID: mdl-25869354
ABSTRACT
Accumulation of stressful events can render individuals susceptible to develop epilepsy and comorbidities. Whether such vulnerability can be predicted and reversed is not known. Here we show that social defeat, although not producing depression by itself, produced in 50% of rats reduced threshold for status epilepticus (SE), accelerated epileptogenesis, and once epilepsy was induced, depression-like profile and cognitive deficits. Low serum brain-derived neurotrophic factor (BDNF) levels measured before SE identified this vulnerable population. Treatment with a BDNF analog before SE prevented the occurrence of comorbidities. Thus, vulnerability to comorbidities after epilepsy onset due to unresolved past stressful events may be predicted and reversed.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Sistema Hipófiso-Suprarrenal
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Medio Social
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Estado Epiléptico
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Estrés Psicológico
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Trastornos del Conocimiento
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Factor Neurotrófico Derivado del Encéfalo
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Depresión
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Sistema Hipotálamo-Hipofisario
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Año:
2015
Tipo del documento:
Article