The epigenetic regulator G9a mediates tolerance to RNA virus infection in Drosophila.
PLoS Pathog
; 11(4): e1004692, 2015 Apr.
Article
en En
| MEDLINE
| ID: mdl-25880195
ABSTRACT
Little is known about the tolerance mechanisms that reduce the negative effects of microbial infection on host fitness. Here, we demonstrate that the histone H3 lysine 9 methyltransferase G9a regulates tolerance to virus infection by shaping the response of the evolutionary conserved Jak-Stat pathway in Drosophila. G9a-deficient mutants are more sensitive to RNA virus infection and succumb faster to infection than wild-type controls, which was associated with strongly increased Jak-Stat dependent responses, but not with major differences in viral load. Genetic experiments indicate that hyperactivated Jak-Stat responses are associated with early lethality in virus-infected flies. Our results identify an essential epigenetic mechanism underlying tolerance to virus infection.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Infecciones por Virus ARN
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Regulación de la Expresión Génica
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N-Metiltransferasa de Histona-Lisina
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Epigénesis Genética
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Drosophila melanogaster
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Tolerancia Inmunológica
Límite:
Animals
Idioma:
En
Año:
2015
Tipo del documento:
Article