From hybrid compounds to targeted drug delivery in antimalarial therapy.
Bioorg Med Chem
; 23(16): 5120-30, 2015 Aug 15.
Article
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| MEDLINE
| ID: mdl-25913864
ABSTRACT
The discovery of new drugs to treat malaria is a continuous effort for medicinal chemists due to the emergence and spread of resistant strains of Plasmodium falciparum to nearly all used antimalarials. The rapid adaptation of the malaria parasite remains a major limitation to disease control. Development of hybrid antimalarial agents has been actively pursued as a promising strategy to overcome the emergence of resistant parasite strains. This review presents the journey that started with simple combinations of two active moieties into one chemical entity and progressed into a delivery/targeted system based on major antimalarial classes of drugs. The rationale for providing different mechanisms of action against a single or additional targets involved in the multiple stages of the parasite's life-cycle is highlighted. Finally, a perspective for this polypharmacologic approach is presented.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Plasmodium
/
Sistemas de Liberación de Medicamentos
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Descubrimiento de Drogas
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Polifarmacología
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Malaria
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Antimaláricos
Límite:
Animals
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Humans
Idioma:
En
Año:
2015
Tipo del documento:
Article