Genetic Changes at the Glycoprotein Editing Site Associated With Serial Passage of Sudan Virus.
J Infect Dis
; 212 Suppl 2: S295-304, 2015 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-25920319
ABSTRACT
Sudan virus (SUDV), like the closely related Ebola virus (EBOV), is a filovirus that causes severe hemorrhagic disease. They both contain an RNA editing site in the glycoprotein gene that controls expression of soluble and full-length protein. We tested the consequences of cell culture passage on the genome sequence at the SUDV editing site locus and determined whether this affected virulence. Passage resulted in expansion of the SUDV editing site, similar to that observed with EBOV. We compared viruses possessing either the wild-type or expanded editing site, using a nonhuman primate model of disease. Despite differences in virus serum titer at one time point, there were no significant differences in time to death or any other measured parameter. These data imply that changes at this locus were not important for SUDV lethality.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Glicoproteínas
/
Edición de ARN
/
Fiebre Hemorrágica Ebola
/
Ebolavirus
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
País como asunto:
Africa
Idioma:
En
Año:
2015
Tipo del documento:
Article