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Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in TH2 cytokine levels.
Schedel, Michaela; Michel, Sven; Gaertner, Vincent D; Toncheva, Antoaneta A; Depner, Martin; Binia, Aristea; Schieck, Maximilian; Rieger, Marie T; Klopp, Norman; von Berg, Andrea; Bufe, Albrecht; Laub, Otto; Rietschel, Ernst; Heinzmann, Andrea; Simma, Burkard; Vogelberg, Christian; Genuneit, Jon; Illig, Thomas; Kabesch, Michael.
  • Schedel M; Department of Pediatrics, National Jewish Health, Denver, Colo; Department of Pediatric Pneumology, Allergy, and Neonatology, Hannover Medical School, Hannover, Germany.
  • Michel S; Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany; Department of Pediatric Pneumology, Allergy, and Neonatology, Hannover Medical School, Hannover, Germany.
  • Gaertner VD; Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany.
  • Toncheva AA; Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany; Department of Pediatric Pneumology, Allergy, and Neonatology, Hannover Medical School, Hannover, Germany.
  • Depner M; Children's Hospital, Ludwig-Maximilians-Universität, Munich, Germany.
  • Binia A; Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany; Nestlé Research Centre, Nutrition & Health Department, Lausanne, Switzerland.
  • Schieck M; Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany; Department of Pediatric Pneumology, Allergy, and Neonatology, Hannover Medical School, Hannover, Germany.
  • Rieger MT; Children's Hospital, Ludwig-Maximilians-Universität, Munich, Germany.
  • Klopp N; Research Group of Molecular Epidemiology, Helmholtz Centre Munich, Neuherberg, Germany; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.
  • von Berg A; Research Institute for the Prevention of Allergic Diseases, Children's Department, Marien-Hospital, Wesel, Germany.
  • Bufe A; Department of Experimental Pneumology, Ruhr-University, Bochum, Germany.
  • Laub O; Children's Hospital, Ludwig-Maximilians-Universität, Munich, Germany.
  • Rietschel E; University Children's Hospital, University of Cologne, Cologne, Germany.
  • Heinzmann A; University Children's Hospital, Albert Ludwigs University, Freiburg, Germany.
  • Simma B; Children's Department, Feldkirch Hospital, Feldkirch, Austria.
  • Vogelberg C; University Children's Hospital, Technical University Dresden, Germany.
  • Genuneit J; Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
  • Illig T; Research Group of Molecular Epidemiology, Helmholtz Centre Munich, Neuherberg, Germany; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.
  • Kabesch M; Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany; Department of Pediatric Pneumology, Allergy, and Neonatology, Hannover Medical School, Hannover, Germany. Electronic address: michael.kabesch@ukr.de.
J Allergy Clin Immunol ; 136(4): 893-903.e14, 2015 Oct.
Article en En | MEDLINE | ID: mdl-25930191
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Asma / Cromosomas Humanos Par 17 / Leucocitos Mononucleares / Células Th2 / Proteínas de la Membrana Tipo de estudio: Clinical_trials / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Male País como asunto: Europa Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Asma / Cromosomas Humanos Par 17 / Leucocitos Mononucleares / Células Th2 / Proteínas de la Membrana Tipo de estudio: Clinical_trials / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Male País como asunto: Europa Idioma: En Año: 2015 Tipo del documento: Article