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Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties.
Kuduk, Scott D; Skudlarek, Jason W; DiMarco, Christina N; Bruno, Joseph G; Pausch, Mark H; O'Brien, Julie A; Cabalu, Tamara D; Stevens, Joanne; Brunner, Joseph; Tannenbaum, Pamela L; Garson, Susan L; Savitz, Alan T; Harrell, Charles M; Gotter, Anthony L; Winrow, Christopher J; Renger, John J; Coleman, Paul J.
  • Kuduk SD; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA. Electronic address: skuduk@noviratherapeutics.com.
  • Skudlarek JW; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA.
  • DiMarco CN; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA.
  • Bruno JG; Department of Pharmacology, Merck Research Laboratories, West Point, PA 19486, USA.
  • Pausch MH; Department of Pharmacology, Merck Research Laboratories, West Point, PA 19486, USA.
  • O'Brien JA; Department of Pharmacology, Merck Research Laboratories, West Point, PA 19486, USA.
  • Cabalu TD; Department of Drug Metabolism, Merck Research Laboratories, West Point, PA 19486, USA.
  • Stevens J; Department of Pharmacology, Merck Research Laboratories, West Point, PA 19486, USA.
  • Brunner J; Department of Pharmacology, Merck Research Laboratories, West Point, PA 19486, USA.
  • Tannenbaum PL; Department of Pharmacology, Merck Research Laboratories, West Point, PA 19486, USA.
  • Garson SL; Department of Neuroscience, Merck Research Laboratories, West Point, PA 19486, USA.
  • Savitz AT; Department of Neuroscience, Merck Research Laboratories, West Point, PA 19486, USA.
  • Harrell CM; Department of Neuroscience, Merck Research Laboratories, West Point, PA 19486, USA.
  • Gotter AL; Department of Neuroscience, Merck Research Laboratories, West Point, PA 19486, USA.
  • Winrow CJ; Department of Neuroscience, Merck Research Laboratories, West Point, PA 19486, USA.
  • Renger JJ; Department of Neuroscience, Merck Research Laboratories, West Point, PA 19486, USA.
  • Coleman PJ; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA.
Bioorg Med Chem Lett ; 25(12): 2488-92, 2015 Jun 15.
Article en En | MEDLINE | ID: mdl-25981685
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piperidinas / Triazoles / Receptores de Orexina / Antagonistas de los Receptores de Orexina Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piperidinas / Triazoles / Receptores de Orexina / Antagonistas de los Receptores de Orexina Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Año: 2015 Tipo del documento: Article