Success and failure of the cellular immune response against HIV-1.
Nat Immunol
; 16(6): 563-70, 2015 Jun.
Article
en En
| MEDLINE
| ID: mdl-25988888
ABSTRACT
The cellular immune response to HIV-1 has now been studied in extraordinary detail. A very large body of data provides the most likely reasons that the HIV-specific cellular immune response succeeds in a small number of people but fails in most. Understanding the success and failure of the HIV-specific cellular immune response has implications that extend not only to immunotherapies and vaccines for HIV-1 but also to the cellular immune response in other disease states. This Review focuses on the mechanisms that are most likely responsible for durable and potent immunologic control of HIV-1. Although we now have a detailed picture of the cellular immune responses to HIV-1, important questions remain regarding the nature of these responses and how they arise.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Infecciones por VIH
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VIH-1
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Vacunas contra el SIDA
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Inmunidad Celular
Límite:
Animals
/
Humans
Idioma:
En
Año:
2015
Tipo del documento:
Article