Alpha 1-antitrypsin serum levels in widespread bronchiectasis.
Respir Med
; 83(2): 119-21, 1989 Mar.
Article
en En
| MEDLINE
| ID: mdl-2602595
ABSTRACT
This study found significantly higher serum levels of alpha 1-antitrypsin (alpha 1-AT) in 35 patients with widespread bronchiectasis compared with healthy controls. The results are in contradiction with a previous study and four case reports which found an association between alpha 1-AT deficiency and bronchiectasis. However, the validity of the association has been questioned in the literature on the grounds that most of the patients in those reports had other possible aetiologies for their bronchiectasis. We believe the raised level of alpha 1-AT in our patients represents a non-specific acute phase response to bronchial infection. Further studies are needed to clarify whether bronchiectasis, like emphysema, can be a manifestation of alpha 1-AT deficiency.
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Banco de datos:
MEDLINE
Asunto principal:
Bronquiectasia
/
Alfa 1-Antitripsina
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
1989
Tipo del documento:
Article