Plasmodium falciparum genetic crosses in a humanized mouse model.
Nat Methods
; 12(7): 631-3, 2015 Jul.
Article
en En
| MEDLINE
| ID: mdl-26030447
ABSTRACT
Genetic crosses of phenotypically distinct strains of the human malaria parasite Plasmodium falciparum are a powerful tool for identifying genes controlling drug resistance and other key phenotypes. Previous studies relied on the isolation of recombinant parasites from splenectomized chimpanzees, a research avenue that is no longer available. Here we demonstrate that human-liver chimeric mice support recovery of recombinant progeny for the identification of genetic determinants of parasite traits and adaptations.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Plasmodium falciparum
/
Cruzamientos Genéticos
Límite:
Animals
/
Humans
Idioma:
En
Año:
2015
Tipo del documento:
Article