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TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and Enhanced In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus.
Kaul, Malvika; Mark, Lilly; Zhang, Yongzheng; Parhi, Ajit K; Lyu, Yi Lisa; Pawlak, Joan; Saravolatz, Stephanie; Saravolatz, Louis D; Weinstein, Melvin P; LaVoie, Edmond J; Pilch, Daniel S.
  • Kaul M; Department of Pharmacology, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA.
  • Mark L; TAXIS Pharmaceuticals, Inc., North Brunswick, New Jersey, USA Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers-The State University of New Jersey, Piscataway, New Jersey, USA.
  • Zhang Y; TAXIS Pharmaceuticals, Inc., North Brunswick, New Jersey, USA.
  • Parhi AK; TAXIS Pharmaceuticals, Inc., North Brunswick, New Jersey, USA Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers-The State University of New Jersey, Piscataway, New Jersey, USA.
  • Lyu YL; Department of Pharmacology, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA.
  • Pawlak J; St. John Hospital and Medical Center, Detroit, Michigan, USA.
  • Saravolatz S; St. John Hospital and Medical Center, Detroit, Michigan, USA.
  • Saravolatz LD; St. John Hospital and Medical Center, Detroit, Michigan, USA Wayne State University School of Medicine, Detroit, Michigan, USA.
  • Weinstein MP; Department of Medicine (Infectious Disease), Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA Department of Pathology and Laboratory Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
  • LaVoie EJ; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers-The State University of New Jersey, Piscataway, New Jersey, USA.
  • Pilch DS; Department of Pharmacology, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA pilchds@rwjms.rutgers.edu.
Antimicrob Agents Chemother ; 59(8): 4845-55, 2015 Aug.
Article en En | MEDLINE | ID: mdl-26033735
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Benzamidas / Profármacos / Resistencia a la Meticilina / Proteínas del Citoesqueleto / Staphylococcus aureus Resistente a Meticilina Límite: Animals / Humans Idioma: En Año: 2015 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Benzamidas / Profármacos / Resistencia a la Meticilina / Proteínas del Citoesqueleto / Staphylococcus aureus Resistente a Meticilina Límite: Animals / Humans Idioma: En Año: 2015 Tipo del documento: Article