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Risk factors for new onset diabetes mellitus after liver transplantation: A meta-analysis.
Li, Da-Wei; Lu, Tian-Fei; Hua, Xiang-Wei; Dai, Hui-Juan; Cui, Xiao-Lan; Zhang, Jian-Jian; Xia, Qiang.
  • Li DW; Da-Wei Li, Tian-Fei Lu, Xiang-Wei Hua, Hui-Juan Dai, Xiao-Lan Cui, Jian-Jian Zhang, Qiang Xia, Department of Liver Surgery and Liver Transplantation Center, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
  • Lu TF; Da-Wei Li, Tian-Fei Lu, Xiang-Wei Hua, Hui-Juan Dai, Xiao-Lan Cui, Jian-Jian Zhang, Qiang Xia, Department of Liver Surgery and Liver Transplantation Center, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
  • Hua XW; Da-Wei Li, Tian-Fei Lu, Xiang-Wei Hua, Hui-Juan Dai, Xiao-Lan Cui, Jian-Jian Zhang, Qiang Xia, Department of Liver Surgery and Liver Transplantation Center, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
  • Dai HJ; Da-Wei Li, Tian-Fei Lu, Xiang-Wei Hua, Hui-Juan Dai, Xiao-Lan Cui, Jian-Jian Zhang, Qiang Xia, Department of Liver Surgery and Liver Transplantation Center, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
  • Cui XL; Da-Wei Li, Tian-Fei Lu, Xiang-Wei Hua, Hui-Juan Dai, Xiao-Lan Cui, Jian-Jian Zhang, Qiang Xia, Department of Liver Surgery and Liver Transplantation Center, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
  • Zhang JJ; Da-Wei Li, Tian-Fei Lu, Xiang-Wei Hua, Hui-Juan Dai, Xiao-Lan Cui, Jian-Jian Zhang, Qiang Xia, Department of Liver Surgery and Liver Transplantation Center, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
  • Xia Q; Da-Wei Li, Tian-Fei Lu, Xiang-Wei Hua, Hui-Juan Dai, Xiao-Lan Cui, Jian-Jian Zhang, Qiang Xia, Department of Liver Surgery and Liver Transplantation Center, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
World J Gastroenterol ; 21(20): 6329-40, 2015 May 28.
Article en En | MEDLINE | ID: mdl-26034369
ABSTRACT

AIM:

To determine the risk factors for new-onset diabetes mellitus (NODM) after liver transplantation by conducting a systematic review and meta-analysis.

METHODS:

We electronically searched the databases of MEDLINE, EMBASE and the Cochrane Library from January 1980 to December 2013 to identify relevant studies reporting risk factors for NODM after liver transplantation. Two authors independently assessed the trials for inclusion and extracted the data. Discrepancies were resolved in consultation with a third reviewer. All statistical analyses were performed with the RevMan5.0 software (The Cochrane Collaboration, Oxford, United Kingdom). Pooled odds ratios (OR) or weighted mean differences (WMD) with 95% confidence intervals (CIs) were calculated using either a fixed effects or a random effects model, based on the presence (I (2) < 50%) or absence (I (2) > 50%) of significant heterogeneity.

RESULTS:

Twenty studies with 4580 patients were included in the meta-analysis, all of which were retrospective. The meta-analysis identified the following significant risk factors hepatitis C virus (HCV) infection (OR = 2.68; 95%CI 1.92-3.72); a family history of diabetes (OR = 1.69, 95%CI 1.09-2.63, P < 0.00001); male gender (OR = 1.53; 95%CI 1.24-1.90; P < 0.0001); impaired fasting glucose (IFG; OR = 3.27; 95%CI 1.84-5.81; P < 0.0001); a family history of diabetes (OR = 1.69; 95%CI 1.09-2.63; P = 0.02); use of tacrolimus (OR = 1.34; 95%CI 1.03-1.76; P = 0.03) and body mass index (BMI)(WMD = 1.19, 95%CI 0.69-1.68, P < 0.00001). Other factors, such as hepatitis B virus infection and alcoholism, were not found to be associated with the incidence of NODM.

CONCLUSION:

The study showed that HCV infection, IFG, a family history of diabetes, male gender, tacrolimus and BMI are risk factors for NODM after liver transplantation.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trasplante de Hígado / Diabetes Mellitus Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Female / Humans / Male Idioma: En Año: 2015 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trasplante de Hígado / Diabetes Mellitus Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Female / Humans / Male Idioma: En Año: 2015 Tipo del documento: Article