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Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.
Schreiber, Stuart L; Kotz, Joanne D; Li, Min; Aubé, Jeffrey; Austin, Christopher P; Reed, John C; Rosen, Hugh; White, E Lucile; Sklar, Larry A; Lindsley, Craig W; Alexander, Benjamin R; Bittker, Joshua A; Clemons, Paul A; de Souza, Andrea; Foley, Michael A; Palmer, Michelle; Shamji, Alykhan F; Wawer, Mathias J; McManus, Owen; Wu, Meng; Zou, Beiyan; Yu, Haibo; Golden, Jennifer E; Schoenen, Frank J; Simeonov, Anton; Jadhav, Ajit; Jackson, Michael R; Pinkerton, Anthony B; Chung, Thomas D Y; Griffin, Patrick R; Cravatt, Benjamin F; Hodder, Peter S; Roush, William R; Roberts, Edward; Chung, Dong-Hoon; Jonsson, Colleen B; Noah, James W; Severson, William E; Ananthan, Subramaniam; Edwards, Bruce; Oprea, Tudor I; Conn, P Jeffrey; Hopkins, Corey R; Wood, Michael R; Stauffer, Shaun R; Emmitte, Kyle A.
  • Schreiber SL; Probe Development Center, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Center for the Science of
  • Kotz JD; Probe Development Center, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: jkotz@broadinstitute.org.
  • Li M; Johns Hopkins School of Medicine Ion Channel Center, Baltimore, MD 21205, USA.
  • Aubé J; University of Kansas Specialized Chemistry Center, Lawrence, KS 66045, USA; Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, 66045, USA.
  • Austin CP; NIH Chemical Genomics Center, National Institutes of Health, Rockville, MD 20850, USA; National Center for Advancing Translational Sciences, Bethesda, MD 20892, USA.
  • Reed JC; Conrad Prebys Center for Chemical Genomics, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, and Lake Nona, FL 32827, USA.
  • Rosen H; Molecular Screening Center, The Scripps Research Institute, La Jolla, CA 92037, and Jupiter, FL 33458, USA; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • White EL; Southern Research Specialized Biocontainment Screening Center, Southern Research Institute, Birmingham, AL 35205, USA.
  • Sklar LA; University of New Mexico Center for Molecular Discovery, Albuquerque, NM 87131, USA; Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, 87131, USA.
  • Lindsley CW; The Vanderbilt Specialized Chemistry Center for Accelerated Probe Development, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
  • Alexander BR; Probe Development Center, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Bittker JA; Probe Development Center, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Center for the Development of Therapeutics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Clemons PA; Probe Development Center, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • de Souza A; Probe Development Center, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Foley MA; Probe Development Center, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Palmer M; Probe Development Center, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Shamji AF; Probe Development Center, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Wawer MJ; Probe Development Center, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • McManus O; Johns Hopkins School of Medicine Ion Channel Center, Baltimore, MD 21205, USA.
  • Wu M; Johns Hopkins School of Medicine Ion Channel Center, Baltimore, MD 21205, USA.
  • Zou B; Johns Hopkins School of Medicine Ion Channel Center, Baltimore, MD 21205, USA.
  • Yu H; Johns Hopkins School of Medicine Ion Channel Center, Baltimore, MD 21205, USA.
  • Golden JE; University of Kansas Specialized Chemistry Center, Lawrence, KS 66045, USA.
  • Schoenen FJ; University of Kansas Specialized Chemistry Center, Lawrence, KS 66045, USA.
  • Simeonov A; NIH Chemical Genomics Center, National Institutes of Health, Rockville, MD 20850, USA; National Center for Advancing Translational Sciences, Bethesda, MD 20892, USA.
  • Jadhav A; NIH Chemical Genomics Center, National Institutes of Health, Rockville, MD 20850, USA; National Center for Advancing Translational Sciences, Bethesda, MD 20892, USA.
  • Jackson MR; Conrad Prebys Center for Chemical Genomics, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, and Lake Nona, FL 32827, USA.
  • Pinkerton AB; Conrad Prebys Center for Chemical Genomics, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, and Lake Nona, FL 32827, USA.
  • Chung TD; Conrad Prebys Center for Chemical Genomics, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, and Lake Nona, FL 32827, USA.
  • Griffin PR; Molecular Screening Center, The Scripps Research Institute, La Jolla, CA 92037, and Jupiter, FL 33458, USA; Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL, 33458, USA.
  • Cravatt BF; Molecular Screening Center, The Scripps Research Institute, La Jolla, CA 92037, and Jupiter, FL 33458, USA; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Hodder PS; Molecular Screening Center, The Scripps Research Institute, La Jolla, CA 92037, and Jupiter, FL 33458, USA.
  • Roush WR; Molecular Screening Center, The Scripps Research Institute, La Jolla, CA 92037, and Jupiter, FL 33458, USA; Department of Chemistry, The Scripps Research Institute, Jupiter, FL, 33458, USA.
  • Roberts E; Molecular Screening Center, The Scripps Research Institute, La Jolla, CA 92037, and Jupiter, FL 33458, USA.
  • Chung DH; Southern Research Specialized Biocontainment Screening Center, Southern Research Institute, Birmingham, AL 35205, USA.
  • Jonsson CB; Southern Research Specialized Biocontainment Screening Center, Southern Research Institute, Birmingham, AL 35205, USA.
  • Noah JW; Southern Research Specialized Biocontainment Screening Center, Southern Research Institute, Birmingham, AL 35205, USA.
  • Severson WE; Southern Research Specialized Biocontainment Screening Center, Southern Research Institute, Birmingham, AL 35205, USA.
  • Ananthan S; Southern Research Specialized Biocontainment Screening Center, Southern Research Institute, Birmingham, AL 35205, USA.
  • Edwards B; University of New Mexico Center for Molecular Discovery, Albuquerque, NM 87131, USA; Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, 87131, USA.
  • Oprea TI; University of New Mexico Center for Molecular Discovery, Albuquerque, NM 87131, USA; Department of Internal Medicine, University of New Mexico, Albuquerque, NM, 87131, USA.
  • Conn PJ; The Vanderbilt Specialized Chemistry Center for Accelerated Probe Development, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
  • Hopkins CR; The Vanderbilt Specialized Chemistry Center for Accelerated Probe Development, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
  • Wood MR; The Vanderbilt Specialized Chemistry Center for Accelerated Probe Development, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
  • Stauffer SR; The Vanderbilt Specialized Chemistry Center for Accelerated Probe Development, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Emmitte KA; The Vanderbilt Specialized Chemistry Center for Accelerated Probe Development, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Cell ; 161(6): 1252-65, 2015 Jun 04.
Article en En | MEDLINE | ID: mdl-26046436
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Bibliotecas de Moléculas Pequeñas / Descubrimiento de Drogas Límite: Animals / Humans País como asunto: America do norte Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Bibliotecas de Moléculas Pequeñas / Descubrimiento de Drogas Límite: Animals / Humans País como asunto: America do norte Idioma: En Año: 2015 Tipo del documento: Article